C F van Kreijl
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Explore the profile of C F van Kreijl including associated specialties, affiliations and a list of published articles.
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40
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Recent Articles
1.
van Kreijl C, McAnulty P, Beems R, VYNCKIER A, van Steeg H, Fransson-Steen R, et al.
Toxicol Pathol
. 2001 Nov;
29 Suppl:117-27.
PMID: 11695547
DNA repair deficient Xpa-/- and Xpa-/-/p53+/- knock-out mice in a C57BL/6 genetic background, referred to as respectively the XPA and XPA/p53 model, were investigated in the international collaborative research program...
2.
van Steeg H, De Vries A, van Oostrom CTh , van Benthem J, Beems R, van Kreijl C
Toxicol Pathol
. 2001 Nov;
29 Suppl:109-16.
PMID: 11695546
Xeroderma pigmentosum (XP) is a rare autosomal recessive disease in which repair of ultraviolet (UV)-induced DNA damage is impaired or is totally absent due to mutations in genes controlling the...
3.
Klein J, Beems R, Zwart P, Hamzink M, Zomer G, van Steeg H, et al.
Carcinogenesis
. 2001 Apr;
22(4):619-26.
PMID: 11285198
The effects of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in DNA repair deficient XPA(-/-) mice. The nullizygous XPA-knockout mice, which lack a functional nucleotide excision repair (NER) pathway, were...
4.
van Oostrom C, Boeve M, van den Berg J, De Vries A, Dolle M, Beems R, et al.
Environ Mol Mutagen
. 1999 Oct;
34(2-3):124-30.
PMID: 10529736
XPA-deficient mice have a complete deficiency in nucleotide excision repair, and as such they display a cancer predisposition after exposure to several carcinogens. Besides being sensitive to genotoxic agents applied...
5.
de Boer J, van Steeg H, Berg R, Garssen J, de Wit J, van Oostrum C, et al.
Cancer Res
. 1999 Jul;
59(14):3489-94.
PMID: 10416615
Patients with the nucleotide excision repair (NER) disorder xeroderma pigmentosum (XP) are highly predisposed to develop sunlight-induced skin cancer, in remarkable contrast to photosensitive NER-deficient trichothiodystrophy (TTD) patients carrying mutations...
6.
van Kreijl C, van Steeg H
Toxicol Pathol
. 1998 Dec;
26(6):757-8.
PMID: 9864092
No abstract available.
7.
van Kreijl C, van der Houven van Oordt C, Kroese E, Sorensen I, Breuer M, Storer R
Toxicol Pathol
. 1998 Dec;
26(6):750-6.
PMID: 9864091
The value of the chronic rodent carcinogenicity assay in adequately predicting cancer risk in humans has become a matter of debate over the past few years. Therefore, more rapid and...
8.
van Steeg H, Klein H, Beems R, van Kreijl C
Toxicol Pathol
. 1998 Dec;
26(6):742-9.
PMID: 9864090
At present (putative) human carcinogens are identified via epidemiological studies and testing using the chronic 2-yr rodent bioassay. Both methods have severe limitations in that they are slow, insensitive, expensive,...
9.
van Kranen H, van Iersel P, Rijnkels J, Beems D, Alink G, van Kreijl C
Carcinogenesis
. 1998 Oct;
19(9):1597-601.
PMID: 9771930
The variation in colorectal cancer (CRC) incidence worldwide strongly suggests a role for dietary influences. Based on epidemiological data, protective effects of vegetables and fruit intake on CRC are widely...
10.
Sorensen I, Kristiansen E, Mortensen A, Nicolaisen G, Wijnands J, van Kranen H, et al.
Cancer Lett
. 1998 Sep;
130(1-2):217-25.
PMID: 9751277
Data from epidemiological studies suggest that isoflavones in soy may have a protective effect on the development of colon cancer in humans. Therefore, we have investigated whether soy isoflavones will...