H Phillip Koeffler
Overview
Explore the profile of H Phillip Koeffler including associated specialties, affiliations and a list of published articles.
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Articles
416
Citations
17416
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Recent Articles
1.
The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer
Nam C, Huang G, Zheng Y, Zhao H, Pan Y, Hu B, et al.
J Exp Med
. 2025 Feb;
222(4).
PMID: 39964485
Upper aerodigestive squamous cell carcinoma (UASCC) presents significant challenges in clinical management due to its aggressive nature. Here, we elucidate the role of MLL3 mutations as early, clonal genomic events...
2.
Wang R, Wang S, Mi Y, Huang T, Wang J, Ni J, et al.
Br J Cancer
. 2025 Feb;
PMID: 39900986
Background: Prostate cancer (PCa) is a heterogeneous disease affecting over 14% of the male population worldwide. Although patients often respond positively to initial treatments within the first 2-3 years, many...
3.
Kong S, Pan H, Zhang Y, Wang F, Chen J, Dong J, et al.
Oncogene
. 2025 Jan;
PMID: 39863749
Ferroptosis is a unique modality of regulated cell death induced by excessive lipid peroxidation, playing a crucial role in tumor suppression and providing potential therapeutic strategy for cancer treatment. Here,...
4.
5.
Wang R, Pan Y, Zhang L, Wang J, Ni J, Ding Y, et al.
Int J Biol Macromol
. 2024 Aug;
278(Pt 3):134844.
PMID: 39168191
Stachyose (STA) is a prebiotic with poor oral bioavailability. In this study, we developed stachyose caproate (C6-STA), as a novel STA derivative, to demonstrate its high adsorption rate via oral...
6.
Hu K, Xie L, Wu W, Zhang J, Li Y, He J, et al.
Int J Biol Sci
. 2024 Jun;
20(8):3140-3155.
PMID: 38904029
Cysteine-rich angiogenic inducer 61 (CYR61), also called CCN1, has long been characterized as a secretory protein. Nevertheless, the intracellular function of CYR61 remains unclear. Here, we found that CYR61 is...
7.
Nam C, Li L, Yang Q, Ziman B, Zhao H, Hu B, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(26):e2320835121.
PMID: 38900797
Upper aerodigestive squamous cell carcinoma (UASCC) is a common and aggressive malignancy with few effective therapeutic options. Here, we investigate amino acid metabolism in this cancer, surprisingly noting that UASCC...
8.
Ong K, Mok M, Niibori-Nambu A, Du L, Yanagida M, Wang C, et al.
Exp Hematol
. 2024 Jun;
137:104255.
PMID: 38876252
The genetic lesions that drive acute megakaryoblastic leukemia (AMKL) have not been fully elucidated. To search for genetic alterations in AMKL, we performed targeted deep sequencing in 34 AMKL patient...
9.
Jiang Y, Zheng Y, Zhang Y, Kong S, Dong J, Wang F, et al.
Nat Commun
. 2024 Mar;
15(1):2484.
PMID: 38509096
Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved in several types of advanced SCCs. However, low response...
10.
Lao Z, Ding L, Sun Q, Jia L, Yan B, Ng A, et al.
Clin Cancer Res
. 2024 Mar;
30(10):2170-2180.
PMID: 38437679
Purpose: DNA methylation alterations are widespread in acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), some of which appear to have evolved independently of somatic mutations in epigenetic regulators. Although...