De-Chen Lin
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Explore the profile of De-Chen Lin including associated specialties, affiliations and a list of published articles.
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Articles
100
Citations
5780
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Recent Articles
1.
The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer
Nam C, Huang G, Zheng Y, Zhao H, Pan Y, Hu B, et al.
J Exp Med
. 2025 Feb;
222(4).
PMID: 39964485
Upper aerodigestive squamous cell carcinoma (UASCC) presents significant challenges in clinical management due to its aggressive nature. Here, we elucidate the role of MLL3 mutations as early, clonal genomic events...
2.
Zhao H, Park Y, Zheng Y, Mao Q, Collet C, Hu B, et al.
bioRxiv
. 2025 Feb;
PMID: 39896470
Upper aerodigestive squamous cell carcinoma (UASCC) is an aggressive and lethal neoplasm, with its early neoplastic transformation mechanisms remaining poorly understood. Here, we characterize over 25 genetically-defined organoid models derived...
3.
Liang Y, Liu M, Liu B, Ziman B, Peng G, Mao Q, et al.
Epigenetics Chromatin
. 2025 Jan;
18(1):6.
PMID: 39833880
Background: Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer. This modification forms large chromatin domains, known as Large Organized Chromatin...
4.
Vistoso Monreal A, Zhao H, Sedghizadeh P, Lin D
Cell Rep Med
. 2024 Jul;
5(7):101650.
PMID: 39019014
Gastric cancer poses diverse treatment challenges due to its high tumor heterogeneity. Through the use of patient-derived tumor organoid (PDO) models, new research has identified genes and molecular signatures that...
5.
Um J, Zheng Y, Mao Q, Nam C, Zhao H, Koh Y, et al.
bioRxiv
. 2024 Jul;
PMID: 39005427
Head and Neck Squamous Cell Carcinoma (HNSCC) remains a significant health burden due to tumor heterogeneity and treatment resistance, emphasizing the need for improved biological understanding and tailored therapies. This...
6.
Nam C, Li L, Yang Q, Ziman B, Zhao H, Hu B, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(26):e2320835121.
PMID: 38900797
Upper aerodigestive squamous cell carcinoma (UASCC) is a common and aggressive malignancy with few effective therapeutic options. Here, we investigate amino acid metabolism in this cancer, surprisingly noting that UASCC...
7.
Jiang Y, Zheng Y, Zhang Y, Kong S, Dong J, Wang F, et al.
Nat Commun
. 2024 Mar;
15(1):2484.
PMID: 38509096
Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved in several types of advanced SCCs. However, low response...
8.
Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, et al.
Cell Death Dis
. 2024 Feb;
15(2):152.
PMID: 38373993
Unlike most cancer types, the incidence of esophageal adenocarcinoma (EAC) has rapidly escalated in the western world over recent decades. Using whole genome bisulfite sequencing (WGBS), we identify the transcription...
9.
Jiang Y, Zhao H, Kong S, Zhou D, Dong J, Cheng Y, et al.
Dis Model Mech
. 2024 Jan;
17(1).
PMID: 38258518
Organoid culture systems are very powerful models that recapitulate in vivo organ development and disease pathogenesis, offering great promise in basic research, drug screening and precision medicine. However, the application...
10.
Zhang L, Zheng Y, Chien W, Ziman B, Billet S, Koeffler H, et al.
Cancers (Basel)
. 2023 Nov;
15(22).
PMID: 38001638
ARID1A, a member of the chromatin remodeling SWI/SNF complex, is frequently lost in many cancer types, including esophageal adenocarcinoma (EAC). Here, we study the impact of ARID1A deficiency on the...