Gwendal Dujardin
Overview
Explore the profile of Gwendal Dujardin including associated specialties, affiliations and a list of published articles.
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22
Citations
1124
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Recent Articles
1.
Zanetti A, Dujardin G, Fares-Taie L, Amiel J, Roger J, Audo I, et al.
Nat Commun
. 2024 Nov;
15(1):10096.
PMID: 39572588
Here we conduct a study involving 12 individuals with retinal dystrophy, neurological impairment, and skeletal abnormalities, with special focus on GPATCH11, a lesser-known G-patch domain-containing protein, regulator of RNA metabolism....
2.
Jonchere V, Montemont H, Le Scanf E, Siret A, Letourneur Q, Tubacher E, et al.
Genome Biol
. 2024 Aug;
25(1):210.
PMID: 39107855
Background: Microsatellite instability (MSI) due to mismatch repair deficiency (dMMR) is common in colorectal cancer (CRC). These cancers are associated with somatic coding events, but the noncoding pathophysiological impact of...
3.
Zukher I, Dujardin G, Sousa-Luis R, Proudfoot N
Nat Struct Mol Biol
. 2023 Oct;
30(10):1536-1548.
PMID: 37783853
Non-cleaving Cas9 (dCas9) is widely employed to manipulate specific gene loci, often with scant regard for unintended transcriptional effects. We demonstrate here that dCas9 mediates precise RNA polymerase II transcriptional...
4.
Marasco L, Dujardin G, Sousa-Luis R, Liu Y, Stigliano J, Nomakuchi T, et al.
Cell
. 2022 Jun;
185(12):2057-2070.e15.
PMID: 35688133
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot compensate for the...
5.
Sousa-Luis R, Dujardin G, Zukher I, Kimura H, Weldon C, Carmo-Fonseca M, et al.
Mol Cell
. 2021 Mar;
81(9):1935-1950.e6.
PMID: 33735606
Mammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled RNA processing. However, molecular details of such co-transcriptional mechanisms remain obscure, partly because of technical...
6.
Flodrops M, Dujardin G, Busson A, Trouve P, Ka C, Simon B, et al.
Mol Biol Rep
. 2020 Mar;
47(4):3031-3040.
PMID: 32200451
We previously reported a 40-transcripts signature marking the normal mucosa to colorectal adenocarcinoma transition. Eight of these mRNAs also showed splicing alterations, including a specific intron 3 retention in tissue...
7.
Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan-Wong S, Dhir S, et al.
Mol Cell
. 2018 Nov;
72(6):970-984.e7.
PMID: 30449723
Extensive tracts of the mammalian genome that lack protein-coding function are still transcribed into long noncoding RNA. While these lncRNAs are generally short lived, length restricted, and non-polyadenylated, how their...
8.
Munoz M, Nieto Moreno N, Giono L, Cambindo Botto A, Dujardin G, Bastianello G, et al.
Cell Rep
. 2017 Mar;
18(12):2868-2879.
PMID: 28329680
We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only...
9.
Dujardin G, Daguenet E, Bernard D, Flodrops M, Durand S, Chauveau A, et al.
Med Sci (Paris)
. 2017 Jan;
32(12):1103-1110.
PMID: 28044974
Pre-mRNA splicing is an obligatory step required to assemble the vast majority of mRNAs in eukaryotes. In humans, each gene gives rise to at least two transcripts, with an average...
10.
Guerrero S, Dujardin G, Cabrera-Andrade A, Paz-Y-Mino C, Indacochea A, Ingles-Ferrandiz M, et al.
PLoS One
. 2016 Aug;
11(8):e0160428.
PMID: 27479083
Electronic laboratory notebooks (ELNs) will probably replace paper laboratory notebooks (PLNs) in academic research due to their advantages in data recording, sharing and security. Despite several reports describing technical characteristics...