Rui Sousa-Luis
Overview
Explore the profile of Rui Sousa-Luis including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
7
Citations
98
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zanetti A, Dujardin G, Fares-Taie L, Amiel J, Roger J, Audo I, et al.
Nat Commun
. 2024 Nov;
15(1):10096.
PMID: 39572588
Here we conduct a study involving 12 individuals with retinal dystrophy, neurological impairment, and skeletal abnormalities, with special focus on GPATCH11, a lesser-known G-patch domain-containing protein, regulator of RNA metabolism....
2.
Davidson L, Rouviere J, Sousa-Luis R, Nojima T, Proudfoot N, Jensen T, et al.
Genes Dev
. 2024 Nov;
38(21-24):998-1019.
PMID: 39496457
The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII-associated cleavage product is then degraded by XRN2, dislodging RNAPII...
3.
Zukher I, Dujardin G, Sousa-Luis R, Proudfoot N
Nat Struct Mol Biol
. 2023 Oct;
30(10):1536-1548.
PMID: 37783853
Non-cleaving Cas9 (dCas9) is widely employed to manipulate specific gene loci, often with scant regard for unintended transcriptional effects. We demonstrate here that dCas9 mediates precise RNA polymerase II transcriptional...
4.
Marasco L, Dujardin G, Sousa-Luis R, Liu Y, Stigliano J, Nomakuchi T, et al.
Cell
. 2022 Jun;
185(12):2057-2070.e15.
PMID: 35688133
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot compensate for the...
5.
Sousa-Luis R, Carmo-Fonseca M
Mol Cell
. 2022 Feb;
82(3):495-496.
PMID: 35120645
Martinez et al. (2022) uncovered a novel function for the most abundant modified nucleoside in RNA. The study shows that uridines at splice sites and splicing regulatory motifs in the...
6.
Silva T, Sousa-Luis R, Fernandes T, Bekman E, Rodrigues C, Vaz S, et al.
Biotechnol Bioeng
. 2021 Apr;
118(7):2781-2803.
PMID: 33871054
Human-induced pluripotent stem cells (iPSCs) have great potential for disease modeling. However, generating iPSC-derived models to study brain diseases remains a challenge. In particular, the ability to recapitulate cerebellar development...
7.
Sousa-Luis R, Dujardin G, Zukher I, Kimura H, Weldon C, Carmo-Fonseca M, et al.
Mol Cell
. 2021 Mar;
81(9):1935-1950.e6.
PMID: 33735606
Mammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled RNA processing. However, molecular details of such co-transcriptional mechanisms remain obscure, partly because of technical...