Guy A Caldwell
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Explore the profile of Guy A Caldwell including associated specialties, affiliations and a list of published articles.
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94
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6672
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Recent Articles
1.
Adams P, Thies J, Sutton J, Millwood J, Caldwell G, Caldwell K, et al.
PeerJ
. 2024 Sep;
12:e18100.
PMID: 39285918
Genetically modified organisms are commonly used in disease research and agriculture but the precise genomic alterations underlying transgenic mutations are often unknown. The position and characteristics of transgenes, including the...
2.
Mack K, Kim H, Barbieri E, Lin J, Braganza S, Jackrel M, et al.
Mol Cell
. 2023 Aug;
83(18):3314-3332.e9.
PMID: 37625404
Hsp104 is an AAA+ protein disaggregase that solubilizes and reactivates proteins trapped in aggregated states. We have engineered potentiated Hsp104 variants to mitigate toxic misfolding of α-synuclein, TDP-43, and FUS...
3.
Caldwell G
Dis Model Mech
. 2023 Jun;
16(6).
PMID: 37309665
On the 15th Anniversary of Disease Models & Mechanisms as a trailblazing venue for the dissemination of discoveries pertaining to human health involving model systems, we celebrate the journey of...
4.
Gaeta A, Willicott K, Willicott C, McKay L, Keogh C, Altman T, et al.
iScience
. 2023 Jun;
26(6):106859.
PMID: 37260751
Failure of inherently protective cellular processes and misfolded protein-associated stress contribute to the progressive loss of dopamine (DA) neurons characteristic of Parkinson's disease (PD). A disease-modifying role for the microbiome...
5.
Starr L, McKay L, Peter K, Seyfarth L, Berkowitz L, Caldwell K, et al.
J Dev Biol
. 2023 May;
11(2).
PMID: 37218814
Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been implicated in several neurological disorders, including Parkinson's disease (PD). Here, we report results of a RNAi screen...
6.
Thies J, Willicott K, Craig M, Greene M, DuGay C, Caldwell G, et al.
Cells
. 2023 May;
12(8).
PMID: 37190079
Oxidative stress is a contributing factor to Parkinson's disease (PD). Considering the prevalence of sporadic PD, environmental exposures are postulated to increase reactive oxygen species and either incite or exacerbate...
7.
Schlein M, Arituluk Z, Stephen C, Caldwell G, Ciesla L, Caldwell K
MicroPubl Biol
. 2023 Apr;
2023.
PMID: 37033702
Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a few (sage) species. Here, six new species were isolated during flowering times from plants native to...
8.
Nourse Jr J, Russell S, Moniz N, Peter K, Seyfarth L, Scott M, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(7):e2210712120.
PMID: 36745808
Whole-exome sequencing of Parkinson's disease (PD) patient DNA identified single-nucleotide polymorphisms (SNPs) in the tyrosine nonreceptor kinase-2 () gene. Although this kinase had a previously demonstrated activity in preventing the...
9.
Mew M, Caldwell K, Caldwell G
Hum Mol Genet
. 2022 Aug;
31(R1):R37-R46.
PMID: 35994032
The exponential accumulation of DNA sequencing data has opened new avenues for discovering the causative roles of single-nucleotide polymorphisms (SNPs) in neurological diseases. The opportunities emerging from this are staggering,...
10.
Gaeta A, Nourse Jr J, Willicott K, McKay L, Keogh C, Peter K, et al.
PLoS Genet
. 2022 Aug;
18(8):e1010115.
PMID: 35984862
The fine-tuning of gene expression is critical for all cellular processes; aberrations in this activity can lead to pathology, and conversely, resilience. As their role in coordinating organismal responses to...