Guy A Caldwell
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Explore the profile of Guy A Caldwell including associated specialties, affiliations and a list of published articles.
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94
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6672
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Recent Articles
11.
Fanning S, Cirka H, Thies J, Jeong J, Niemi S, Yoon J, et al.
NPJ Parkinsons Dis
. 2022 Jun;
8(1):74.
PMID: 35680956
Synucleinopathy (Parkinson's disease (PD); Lewy body dementia) disease-modifying treatments represent a huge unmet medical need. Although the PD-causing protein α-synuclein (αS) interacts with lipids and fatty acids (FA) physiologically and...
12.
Xie C, Zhuang X, Niu Z, Ai R, Lautrup S, Zheng S, et al.
Nat Biomed Eng
. 2022 Jan;
6(1):76-93.
PMID: 34992270
A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating such impaired mitophagy would benefit from the identification...
13.
van der Welle R, Jobling R, Burns C, Sanza P, van der Beek J, Fasano A, et al.
EMBO Mol Med
. 2021 Apr;
13(5):e13258.
PMID: 33851776
Vacuolar protein sorting 41 (VPS41) is as part of the Homotypic fusion and Protein Sorting (HOPS) complex required for lysosomal fusion events and, independent of HOPS, for regulated secretion. Here,...
14.
McGrath K, Agarwal S, Tonelli M, Dergai M, Gaeta A, Shum A, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(12).
PMID: 33723042
Ykt6 is a soluble -ethylmaleimide sensitive factor activating protein receptor (SNARE) critically involved in diverse vesicular fusion pathways. While most SNAREs rely on transmembrane domains for their activity, Ykt6 dynamically...
15.
Nourse Jr J, Harshefi G, Marom A, Karmi A, Cohen Ben-Ami H, Caldwell K, et al.
iScience
. 2021 Mar;
24(3):102140.
PMID: 33665559
Tobacco smoking is a risk factor for several human diseases. Conversely, smoking also reduces the prevalence of Parkinson's disease, whose hallmark is degeneration of dopaminergic neurons (DNs). We use as...
16.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
17.
March Z, Sweeney K, Kim H, Yan X, Castellano L, Jackrel M, et al.
Elife
. 2020 Dec;
9.
PMID: 33319748
The AAA+ protein disaggregase, Hsp104, increases fitness under stress by reversing stress-induced protein aggregation. Natural Hsp104 variants might exist with enhanced, selective activity against neurodegenerative disease substrates. However, natural Hsp104...
18.
Caldwell K, Willicott C, Caldwell G
Dis Model Mech
. 2020 Oct;
13(10).
PMID: 33106318
The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors. The nematode has served as the experimental subject for...
19.
Vaji M, Caldwell G, Caldwell K
MicroPubl Biol
. 2020 Aug;
2020.
PMID: 32844156
No abstract available.
20.
Vaji M, Caldwell G, Caldwell K
MicroPubl Biol
. 2020 Aug;
2020.
PMID: 32844155
No abstract available.