Adam J Harrington
Overview
Explore the profile of Adam J Harrington including associated specialties, affiliations and a list of published articles.
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12
Citations
422
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Recent Articles
1.
McChesney N, Barth J, Rumschlag J, Tan J, Harrington A, Noble K, et al.
J Neurosci
. 2022 Sep;
42(42):8002-8018.
PMID: 36180228
Dysfunction of the peripheral auditory nerve (AN) contributes to dynamic changes throughout the central auditory system, resulting in abnormal auditory processing, including hypersensitivity. Altered sound sensitivity is frequently observed in...
2.
Bjorness T, Kulkarni A, Rybalchenko V, Suzuki A, Bridges C, Harrington A, et al.
Elife
. 2020 Aug;
9.
PMID: 32851972
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene...
3.
Harrington A, Bridges C, Berto S, Blankenship K, Cho J, Assali A, et al.
Biol Psychiatry
. 2020 May;
88(6):488-499.
PMID: 32418612
Background: Microdeletions of the MEF2C gene are linked to a syndromic form of autism termed MEF2C haploinsufficiency syndrome (MCHS). MEF2C hypofunction in neurons is presumed to underlie most of the...
4.
Assali A, Harrington A, Cowan C
Curr Opin Neurobiol
. 2019 May;
59:49-58.
PMID: 31129473
The MEF2 family of transcription factors regulate large programs of gene expression important for the development and maintenance of many tissues, including the brain. MEF2 proteins are regulated by neuronal...
5.
Harrington A, Raissi A, Rajkovich K, Berto S, Kumar J, Molinaro G, et al.
Elife
. 2016 Nov;
5.
PMID: 27779093
Numerous genetic variants associated with are linked to autism, intellectual disability (ID) and schizophrenia (SCZ) - a heterogeneous collection of neurodevelopmental disorders with unclear pathophysiology. MEF2C is highly expressed in...
6.
Harrington A, Yacoubian T, Slone S, Caldwell K, Caldwell G
J Neurosci
. 2012 Feb;
32(6):2142-53.
PMID: 22323726
Disruption of the lysosomal system has emerged as a key cellular pathway in the neurotoxicity of α-synuclein (α-syn) and the progression of Parkinson's disease (PD). A large-scale RNA interference (RNAi)...
7.
Tucci M, Harrington A, Caldwell G, Caldwell K
Methods Mol Biol
. 2011 Sep;
793:129-48.
PMID: 21913098
Ongoing investigations into causes and cures for human movement disorders are important toward the elucidation of diseases, such as Parkinson's disease (PD). The use of animal model systems can provide...
8.
Harrington A, Knight A, Caldwell G, Caldwell K
Methods
. 2011 Jan;
53(3):220-5.
PMID: 21195766
Protein misfolding and aggregation are key pathological features observed in numerous neurodegenerative diseases, including the misfolding of α-synuclein (α-syn) in Parkinson's disease (PD) and β-amyloid in Alzheimer's disease. While this...
9.
Pivtoraiko V, Harrington A, Mader B, Luker A, Caldwell G, Caldwell K, et al.
J Neurochem
. 2010 Jun;
114(4):1193-204.
PMID: 20534000
We have shown previously that the plecomacrolide antibiotics bafilomycin A1 and B1 significantly attenuate cerebellar granule neuron death resulting from agents that disrupt lysosome function. To further characterize bafilomycin-mediated cytoprotection,...
10.
Harrington A, Hamamichi S, Caldwell G, Caldwell K
Dev Dyn
. 2010 Jan;
239(5):1282-95.
PMID: 20108318
Parkinson's disease (PD) is an age-related movement disorder resulting, in part, from selective loss of dopaminergic neurons. Both invertebrate and mammalian models have been developed to study the cellular mechanisms...