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Gregory Upert

Explore the profile of Gregory Upert including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 28
Citations 365
Followers 0
Related Specialties
Chemistry
Science
Biochemistry
Top 10 Co-Authors
Nicolas Gilles
Gilles Mourier
Loic Quinton
Edwin De Pauw
Denis Servent
Daniel Obrecht
Anatol Luther
Philippe Massonnet
Sebastian Hiller
Jean R N Haler
Published In
J Am Soc Mass Spectrom
J Med Chem
Nat Commun
Chem Commun (Camb)
Anal Chem
Affiliations
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Recent Articles
11.
Chimeric peptidomimetic antibiotics against Gram-negative bacteria
Luther A, Urfer M, Zahn M, Muller M, Wang S, Mondal M, et al.
Nature . 2019 Oct; 576(7787):452-458. PMID: 31645764
There is an urgent need for new antibiotics against Gram-negative pathogens that are resistant to carbapenem and third-generation cephalosporins, against which antibiotics of last resort have lost most of their...
12.
Disulfide Connectivity Analysis of Peptides Bearing Two Intramolecular Disulfide Bonds Using MALDI In-Source Decay
Massonnet P, Haler J, Upert G, Smargiasso N, Mourier G, Gilles N, et al.
J Am Soc Mass Spectrom . 2018 Jul; 29(10):1995-2002. PMID: 29987664
Disulfide connectivity in peptides bearing at least two intramolecular disulfide bonds is highly important for the structure and the biological activity of the peptides. In that context, analytical strategies allowing...
13.
RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia
Christensen S, Hone A, Roux I, Kniazeff J, Pin J, Upert G, et al.
Front Cell Neurosci . 2017 Aug; 11:219. PMID: 28785206
Transcripts for α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are found in diverse tissues. The function of α9α10 nAChRs is best known in mechanosensory cochlear hair cells, but elsewhere...
14.
Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins
Blanchet G, Alili D, Protte A, Upert G, Gilles N, Tepshi L, et al.
Sci Rep . 2017 Jun; 7(1):2701. PMID: 28578406
Mamba venoms contain a multiplicity of three-finger fold aminergic toxins known to interact with various α-adrenergic, muscarinic and dopaminergic receptors with different pharmacological profiles. In order to generate novel functions...
15.
Ion Mobility-Mass Spectrometry as a Tool for the Structural Characterization of Peptides Bearing Intramolecular Disulfide Bond(s)
Massonnet P, Haler J, Upert G, Degueldre M, Morsa D, Smargiasso N, et al.
J Am Soc Mass Spectrom . 2016 Aug; 27(10):1637-46. PMID: 27488317
Disulfide bonds are post-translationnal modifications that can be crucial for the stability and the biological activities of natural peptides. Considering the importance of these disulfide bond-containing peptides, the development of...
16.
Combined use of ion mobility and collision-induced dissociation to investigate the opening of disulfide bridges by electron-transfer dissociation in peptides bearing two disulfide bonds
Massonnet P, Upert G, Smargiasso N, Gilles N, Quinton L, De Pauw E
Anal Chem . 2015 Apr; 87(10):5240-6. PMID: 25915795
Disulfide bonds are post-translational modifications (PTMs) often found in peptides and proteins. They increase their stability toward enzymatic degradations and provide the structure and (consequently) the activity of such folded...
17.
Acidosis increases MHC class II-restricted presentation of a protein endowed with a pH-dependent heparan sulfate-binding ability
Knittel D, Savatier A, Upert G, Lortat-Jacob H, Leonetti M
J Immunol . 2015 Mar; 194(8):3601-11. PMID: 25754736
Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed molecules that participate in numerous biological processes. We previously showed that HSPGs expressed on the surface of APCs can serve as receptors for...
18.
High-throughput production of two disulphide-bridge toxins
Upert G, Mourier G, Pastor A, Verdenaud M, Alili D, Servent D, et al.
Chem Commun (Camb) . 2014 Jun; 50(61):8408-11. PMID: 24947561
A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC...
19.
Peptidomic comparison and characterization of the major components of the venom of the giant ant Dinoponera quadriceps collected in four different areas of Brazil
Cologna C, Cardoso J, Jourdan E, Degueldre M, Upert G, Gilles N, et al.
J Proteomics . 2013 Oct; 94:413-22. PMID: 24157790
Biological Significance: For the first time this manuscript describes an extensive proteomics characterization of the D. quadriceps venom. In addition this study reports the variation in venom composition of primitive...
20.
Zinc-selective inhibition of the promiscuous bacterial amide-hydrolase DapE: implications of metal heterogeneity for evolution and antibiotic drug design
Uda N, Upert G, Angelici G, Nicolet S, Schmidt T, Schwede T, et al.
Metallomics . 2013 Sep; 6(1):88-95. PMID: 24057071
The development of resistance to virtually all current antibiotics makes the discovery of new antimicrobial compounds with novel protein targets an urgent challenge. The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is...