Gregory L Sousa
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Explore the profile of Gregory L Sousa including associated specialties, affiliations and a list of published articles.
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16
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1262
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Recent Articles
1.
Sousa G, Bishnoi R, Baxter R, Povelones M
PLoS Pathog
. 2020 Oct;
16(10):e1008985.
PMID: 33045027
The arthropod melanization immune response is activated by extracellular protease cascades predominantly comprised of CLIP-domain serine proteases (CLIP-SPs) and serine protease homologs (CLIP-SPHs). In the malaria vector, Anopheles gambiae, the...
2.
Bishnoi R, Sousa G, Contet A, Day C, Hou C, Profitt L, et al.
Sci Rep
. 2019 Oct;
9(1):15191.
PMID: 31645596
Malaria, the world's most devastating parasitic disease, is transmitted between humans by mosquitoes of the Anopheles genus. An. gambiae is the principal malaria vector in Sub-Saharan Africa. The C-type lectins...
3.
Reyes Ruiz V, Sousa G, Sneed S, Farrant K, Christophides G, Povelones M
PLoS One
. 2019 Apr;
14(4):e0214753.
PMID: 30958840
The complement-like pathway of the African malaria mosquito Anopheles gambiae provides protection against infection by diverse pathogens. A functional requirement for a core set of proteins during infections by rodent...
4.
Williams P, Braine C, Kizhatil K, Foxworth N, Tolman N, Harder J, et al.
Mol Neurodegener
. 2019 Jan;
14(1):6.
PMID: 30670050
Background: Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical neuroinflammatory event damages retinal ganglion cell axons...
5.
Harder J, Braine C, Williams P, Zhu X, MacNicoll K, Sousa G, et al.
Proc Natl Acad Sci U S A
. 2017 Apr;
114(19):E3839-E3848.
PMID: 28446616
Various immune response pathways are altered during early, predegenerative stages of glaucoma; however, whether the early immune responses occur secondarily to or independently of neuronal dysfunction is unclear. To investigate...
6.
Reiner D, Mietlicki-Baase E, McGrath L, Zimmer D, Bence K, Sousa G, et al.
J Neurosci
. 2016 Mar;
36(12):3531-40.
PMID: 27013681
Significance Statement: Glucagon-like peptide-1 receptor (GLP-1R) agonists reduce food intake and are approved by the Food and Drug Administration for the treatment of obesity, but the cellular mechanisms underlying the...
7.
Jay T, Miller C, Cheng P, Graham L, Bemiller S, Broihier M, et al.
J Exp Med
. 2015 Mar;
212(3):287-95.
PMID: 25732305
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms underlying TREM2's involvement...
8.
Howell G, MacNicoll K, Braine C, Soto I, Macalinao D, Sousa G, et al.
Neurobiol Dis
. 2014 Aug;
71:44-52.
PMID: 25132557
The endothelin system is implicated in various human and animal glaucomas. Targeting the endothelin system has great promise as a treatment for human glaucoma, but the cell types involved and...
9.
Williams P, Howell G, Barbay J, Braine C, Sousa G, John S, et al.
PLoS One
. 2013 Aug;
8(8):e72282.
PMID: 23977271
Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and accompanying visual field loss. The common site of...
10.
Howell G, Soto I, Zhu X, Ryan M, Macalinao D, Sousa G, et al.
J Clin Invest
. 2012 Mar;
122(4):1246-61.
PMID: 22426214
Glaucoma is a common ocular disorder that is a leading cause of blindness worldwide. It is characterized by the dysfunction and loss of retinal ganglion cells (RGCs). Although many studies...