Gregory Hamm
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Explore the profile of Gregory Hamm including associated specialties, affiliations and a list of published articles.
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37
Citations
706
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Recent Articles
1.
Ling S, Dexter A, Race A, Sharma S, Hamm G, Polanska U, et al.
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 40019006
The PI3K-mTOR-AKT pathway regulates tumour proliferation, gene expression and metabolism, but pathway inhibition induces heterogeneous feedback reactivation, limiting anti-tumour responses. Measuring heterogeneity of pathway inhibition in tissues using protein biomarker...
2.
Vezzali E, Becker M, Romero-Palomo F, van Heerden M, Chipeaux C, Hamm G, et al.
Toxicol Pathol
. 2025 Feb;
53(1):130-158.
PMID: 39902784
Mass Spectrometry Imaging (MSI) is a powerful tool to understand molecular pathophysiology and therapeutic and toxicity mechanisms, as well as for patient stratification and precision medicine. MSI, a label-free technique...
3.
Sushentsev N, Hamm G, Flint L, Birtles D, Zakirov A, Richings J, et al.
Nat Commun
. 2024 Jul;
15(1):5980.
PMID: 39013948
Hyperpolarised magnetic resonance imaging (HP-C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify...
4.
Pearce S, Cross N, Smith D, Clench M, Flint L, Hamm G, et al.
Metabolites
. 2024 Jun;
14(6).
PMID: 38921450
A multimodal mass spectrometry imaging (MSI) approach was used to investigate the chemotherapy drug-induced response of a Multicellular Tumour Spheroid (MCTS) 3D cell culture model of osteosarcoma (OS). The work...
5.
Sushentsev N, Hamm G, Richings J, McLean M, Horvat Menih I, Ayyappan V, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(49):e2312261120.
PMID: 38011568
While radical prostatectomy remains the mainstay of prostate cancer (PCa) treatment, 20 to 40% of patients develop postsurgical biochemical recurrence (BCR). A particularly challenging clinical cohort includes patients with intermediate-risk...
6.
Staniszewska A, Pilger D, Gill S, Jamal K, Bohin N, Guzzetti S, et al.
Clin Cancer Res
. 2023 Nov;
30(7):1338-1351.
PMID: 37967136
Purpose: We evaluated the properties and activity of AZD9574, a blood-brain barrier (BBB) penetrant selective inhibitor of PARP1, and assessed its efficacy and safety alone and in combination with temozolomide...
7.
Dannhorn A, Doria M, McKenzie J, Inglese P, Swales J, Hamm G, et al.
Metabolites
. 2023 Mar;
13(3).
PMID: 36984817
With increased use of mass spectrometry imaging (MSI) in support of pharmaceutical research and development, there are opportunities to develop analytical pipelines that incorporate exploratory high-performance analysis with higher capacity...
8.
Dannhorn A, Swales J, Hamm G, Strittmatter N, Kudo H, Maglennon G, et al.
Pharmaceuticals (Basel)
. 2022 Nov;
15(11).
PMID: 36355479
Fixation of samples is broadly used prior to the histological evaluation of tissue samples. Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry imaging (MSI) based...
9.
Bruning-Richardson A, Shaw G, Tams D, Brend T, Sanganee H, Barry S, et al.
Cancers (Basel)
. 2022 Aug;
14(15).
PMID: 35954505
The authors wish to make the following corrections to this paper [1][...].
10.
Dannhorn A, Kazanc E, Hamm G, Swales J, Strittmatter N, Maglennon G, et al.
Metabolites
. 2022 Mar;
12(3).
PMID: 35323705
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial information is lost during the extraction and elucidation...