Gregory F Hollis
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Explore the profile of Gregory F Hollis including associated specialties, affiliations and a list of published articles.
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12
Citations
219
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Recent Articles
1.
Behshad E, Klabe R, Margulis A, Becker-Pasha M, Rupar M, Collier P, et al.
Curr Chem Genomics
. 2010 Jun;
4:27-33.
PMID: 20556206
High-throughput screening (HTS) of ~50,000 chemical compounds against phosphorylated and unphosphorylated c-Met, a tyrosine kinase receptor for hepatocyte growth factor (HGF), was carried out in order to compare hit rates,...
2.
Ala P, Gonneville L, Hillman M, Becker-Pasha M, Yue E, Douty B, et al.
J Biol Chem
. 2006 Oct;
281(49):38013-21.
PMID: 17028182
Structural analyses of the protein-tyrosine phosphatase 1B (PTP1B) active site and inhibitor complexes have aided in optimization of a peptide inhibitor containing the novel (S)-isothiazolidinone (IZD) phosphonate mimetic. Potency and...
3.
Ala P, Gonneville L, Hillman M, Becker-Pasha M, Wei M, Reid B, et al.
J Biol Chem
. 2006 Aug;
281(43):32784-95.
PMID: 16916797
Crystal structures of protein-tyrosine phosphatase 1B in complex with compounds bearing a novel isothiazolidinone (IZD) heterocyclic phosphonate mimetic reveal that the heterocycle is highly complementary to the catalytic pocket of...
4.
Yuan C, Lasut A, Wynn R, Neff N, Hollis G, Ramaker M, et al.
Protein Expr Purif
. 2003 May;
29(2):217-22.
PMID: 12767812
The EGF family of receptors belongs to the tyrosine kinase receptor (TKR) family and plays an important role during embryonic and postnatal development and also in the progression of tumors....
5.
Xiang H, Wynn R, Ross O, Ahrens D, ONeil K, Hollis G, et al.
J Chromatogr A
. 2002 Dec;
978(1-2):153-64.
PMID: 12458952
Undesired adsorption of host cell proteins poses a big challenge for immobilized metal-ion affinity chromatography (IMAC) purification. In this study, by using His6-tagged protein Fab OPG C11 from Escherichia coli...
6.
Seiffert D, Stern A, Ebling W, Rossi R, Barrett Y, Wynn R, et al.
Blood
. 2002 Oct;
101(1):58-63.
PMID: 12393571
Thrombocytopenia is a relatively common side effect observed during glycoprotein (GP) IIb/IIIa antagonist therapy. With the oral antagonist roxifiban, we observed thrombocytopenia, defined as 50% reduction of platelets over predose...
7.
Quantitative analysis of c-myc-tagged protein in crude cell extracts using fluorescence polarization
Sun S, Ross O, Hollis G, Wynn R
Anal Biochem
. 2002 Aug;
307(2):287-96.
PMID: 12202246
A fluorescence polarization (FP) assay was developed to determine the concentration of a c-myc-tagged recombinant protein in a crude cell extract. The basis of the assay was a competition between...
8.
Hillman M, Zolotarjova N, Patrick D, McCabe D, Shen K, Corman J, et al.
Protein Expr Purif
. 2002 Aug;
25(3):494-502.
PMID: 12182831
Glycoprotein IIb-IIIa is an abundant platelet receptor of the integrin family that plays a primary role in platelet aggregation. It exists on the platelet surface predominantly in a resting or...
9.
Huber R, Murphy K, Miao B, Link J, Cunningham M, Rupar M, et al.
Gene
. 2002 Jun;
290(1-2):35-43.
PMID: 12062799
Bile acid biosynthesis is regulated by both feed-forward and feedback mechanisms involving a cascade of nuclear hormone receptors. Feed-forward regulation of the rate limiting enzyme in bile acid biosynthesis is...
10.
Billheimer J, Dicker I, Wynn R, Bradley J, Cromley D, Godonis H, et al.
Blood
. 2002 May;
99(10):3540-6.
PMID: 11986205
Glycoprotein (GP) IIb/IIIa antagonists are effective therapeutic agents, but elicit thrombocytopenia with a frequency that approaches 2%. Here, we provide evidence that thrombocytopenia in humans treated with the GP IIb/IIIa...