Robert B Stein
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Explore the profile of Robert B Stein including associated specialties, affiliations and a list of published articles.
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10
Citations
181
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Recent Articles
1.
Mueller L, Wexler R, Lovejoy D, Stein R, Slee A
Pharmacol Res Perspect
. 2024 Dec;
12(6):e70045.
PMID: 39651597
Hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis response can result in anxiety and other neuropsychiatric disorders and effective therapeutics are needed to mitigate this maladaptive response. Here we examined the effects...
2.
Chand D, Savitsky D, Krishnan S, Mednick G, Delepine C, Garcia-Broncano P, et al.
Cancer Discov
. 2024 Jul;
14(12):2407-2429.
PMID: 39083809
This study reveals that Fc-enhanced anti-CTLA-4 harnesses novel mechanisms to overcome the limitations of conventional anti-CTLA-4, effectively treating poorly immunogenic and treatment-refractory cancers. Our findings support the development of a...
3.
Mueller L, Wexler R, Lovejoy D, Stein R, Slee A
Psychopharmacology (Berl)
. 2024 Apr;
241(8):1565-1575.
PMID: 38630316
Rationale: Corticotropin-releasing factor (CRF), the apical stress-inducing hormone, exacerbates stress and addictive behaviors. TCAP-1 is a peptide that directly inhibits both CRF-mediated stress and addiction-related behaviors; however, the direct action...
4.
Patskovsky Y, Natarajan A, Patskovska L, Nyovanie S, Joshi B, Morin B, et al.
Nat Commun
. 2023 Jul;
14(1):4522.
PMID: 37500629
No abstract available.
5.
Patskovsky Y, Natarajan A, Patskovska L, Nyovanie S, Joshi B, Morin B, et al.
Nat Commun
. 2023 Jun;
14(1):3763.
PMID: 37353482
Altered protein phosphorylation in cancer cells often leads to surface presentation of phosphopeptide neoantigens. However, their role in cancer immunogenicity remains unclear. Here we describe a mechanism by which an...
6.
Karapetyan A, Chaipan C, Winkelbach K, Wimberger S, Jeong J, Joshi B, et al.
Front Immunol
. 2019 Nov;
10:2501.
PMID: 31695703
Adoptive T cell therapy using patient T cells redirected to recognize tumor-specific antigens by expressing genetically engineered high-affinity T-cell receptors (TCRs) has therapeutic potential for melanoma and other solid tumors....
7.
Castle J, Uduman M, Pabla S, Stein R, Buell J
Front Immunol
. 2019 Aug;
10:1856.
PMID: 31440245
Mutation-derived neoantigens distinguish tumor from normal cells. T cells can sense the HLA-presented mutations, recognize tumor cells as non-self and destroy them. Therapeutically, immunotherapy antibodies can increase the virulence of...
8.
Seiffert D, Stern A, Ebling W, Rossi R, Barrett Y, Wynn R, et al.
Blood
. 2002 Oct;
101(1):58-63.
PMID: 12393571
Thrombocytopenia is a relatively common side effect observed during glycoprotein (GP) IIb/IIIa antagonist therapy. With the oral antagonist roxifiban, we observed thrombocytopenia, defined as 50% reduction of platelets over predose...
9.
Su C, Salzberg B, Lewis J, Deren J, Kornbluth A, Katzka D, et al.
Am J Gastroenterol
. 2002 Oct;
97(10):2577-84.
PMID: 12385442
Objectives: Tumor necrosis factor-alpha (TNF-alpha) is an important cytokine involved in the pathogenesis of inflammatory bowel disease. The monoclonal antibody to TNF-alpha, infliximab, is effective in treating Crohn's disease. Preclinical...
10.
Dinchuk J, Focht R, Kelley J, Henderson N, Zolotarjova N, Wynn R, et al.
J Biol Chem
. 2002 Jan;
277(15):12970-7.
PMID: 11773073
The BAH genomic locus encodes three distinct proteins: junctin, humbug, and BAH. All three proteins share common exons, but differ significantly based upon the use of alternative terminal exons. The...