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Andrew M Stern

Explore the profile of Andrew M Stern including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 71
Citations 2257
Followers 0
Related Specialties
Science
Neurology
Biology
Top 10 Co-Authors
D Lansing Taylor
Stuart L Schreiber
Albert Gough
Mark E Schurdak
Alykhan F Shamji
Dietmar Seiffert
Mark T Miedel
Dennis J Selkoe
Nicola J Tolliday
Adrian V Lee
Published In
Alzheimers Dement
Proc Natl Acad Sci U S A
Nature
PLoS One
Blood
Affiliations
Soon will be listed here.
Recent Articles
1.
A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Aleman J, K R, Wiegand C, Schurdak M, Vernetti L, Gavlock D, et al.
Commun Biol . 2024 Oct; 7(1):1317. PMID: 39397070
Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of T2DM...
2.
Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy
Xia M, Varmazyad M, Pla-Palacin I, Gavlock D, DeBiasio R, LaRocca G, et al.
Front Cell Dev Biol . 2024 Sep; 12:1423936. PMID: 39324073
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a complex, multisystem disorder driven by multiple...
3.
Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy
Xia M, Varmazyad M, Palacin I, Gavlock D, DeBiasio R, LaRocca G, et al.
bioRxiv . 2024 May; PMID: 38712213
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a complex, multisystem disorder driven by multiple...
4.
A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Aleman J, Ravikumar K, Wiegand C, Schurdak M, Vernetti L, Gavlock D, et al.
bioRxiv . 2024 May; PMID: 38712135
Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in pancreatic islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of...
5.
Tangles, not TANGO: targeting tau aggregates
Stern A, Sperling R
Nat Aging . 2023 Nov; 3(12):1472-1473. PMID: 38012286
No abstract available.
6.
Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system
Negi V, Gavlock D, Miedel M, Lee J, Shun T, Gough A, et al.
Lab Chip . 2023 Sep; 23(20):4514-4527. PMID: 37766577
: COVID-19 pandemic has caused more than 6 million deaths worldwide. Co-morbid conditions such as Type 2 Diabetes (T2D) have increased mortality in COVID-19. With limited translatability of and small...
7.
Soluble oligomers or insoluble fibrils? Scientific commentary on "Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau"
Stern A, Selkoe D
Acta Neuropathol . 2023 Sep; 146(6):861-862. PMID: 37733037
No abstract available.
8.
Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts
Stern A, Pelt K, Liu L, Anderson A, Ostaszewski B, Mapstone M, et al.
Alzheimers Dement . 2023 Jul; 19(12):5755-5764. PMID: 37438872
Introduction: People with Down syndrome (DS) often develop Alzheimer's disease (AD). Here, we asked whether ultrasensitive plasma immunoassays for a tau N-terminal fragment (NT1-tau) and Aβ isoforms predict cognitive impairment....
9.
Anti-dementia bias and Medicare regulation of Alzheimer's disease care
Stern A
Alzheimers Dement . 2023 May; 19(8):3752-3753. PMID: 37222661
No abstract available.
10.
Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains
Stern A, Yang Y, Jin S, Yamashita K, Meunier A, Liu W, et al.
Neuron . 2023 May; 111(13):2012-2020.e4. PMID: 37167969
Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in supernatants following ultracentrifugation of aqueous extracts from Alzheimer's disease (AD) brains and are believed to be upstream initiators...