Gregory C Howard
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Explore the profile of Gregory C Howard including associated specialties, affiliations and a list of published articles.
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12
Citations
352
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Recent Articles
1.
Howard G, Tansey W
Trends Pharmacol Sci
. 2025 Mar;
PMID: 40044536
Ribosomes and ribosome biogenesis (RiBi) are universally corrupted in cancer, fueling the high rates of translation that sustain malignancy and creating opportunities for discriminating therapeutic intervention. Despite longstanding recognition of...
2.
Meyer C, Smith B, Wang J, Teuscher K, Grieb B, Howard G, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2408889121.
PMID: 39167600
WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene expression. WDR5 is tethered to chromatin...
3.
Howard G, Wang J, Rose K, Jones C, Patel P, Tsui T, et al.
bioRxiv
. 2023 Aug;
PMID: 37546802
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the "WIN" site...
4.
Teuscher K, Chowdhury S, Meyers K, Tian J, Sai J, Van Meveren M, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2211297120.
PMID: 36574664
WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of...
5.
Florian A, Woodley C, Wang J, Grieb B, Slota M, Guerrazzi K, et al.
NAR Cancer
. 2022 Mar;
4(1):zcac007.
PMID: 35252869
Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of , which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of is associated with a...
6.
Siladi A, Wang J, Florian A, Thomas L, Creighton J, Matlock B, et al.
Sci Rep
. 2022 Feb;
12(1):1848.
PMID: 35115608
WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule...
7.
Bryan A, Wang J, Howard G, Guarnaccia A, Woodley C, Aho E, et al.
Nucleic Acids Res
. 2020 Jan;
48(6):2924-2941.
PMID: 31996893
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule...
8.
Weissmiller A, Wang J, Lorey S, Howard G, Martinez E, Liu Q, et al.
Nat Commun
. 2019 May;
10(1):2014.
PMID: 31043611
SMARCB1 encodes the SNF5 subunit of the SWI/SNF chromatin remodeler. SNF5 also interacts with the oncoprotein transcription factor MYC and is proposed to stimulate MYC activity. The concept that SNF5...
9.
Aho E, Wang J, Gogliotti R, Howard G, Phan J, Acharya P, et al.
Cell Rep
. 2019 Mar;
26(11):2916-2928.e13.
PMID: 30865883
The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the "WIN site" of WDR5, a well-defined pocket that...
10.
Howard G, Tansey W
Mol Biol Cell
. 2016 Jul;
27(17):2735-41.
PMID: 27385344
The ubiquitin-proteasome system (UPS) influences gene transcription in multiple ways. One way in which the UPS affects transcription centers on transcriptional activators, the function of which can be stimulated by...