David K Flaherty
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Explore the profile of David K Flaherty including associated specialties, affiliations and a list of published articles.
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32
Citations
746
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Recent Articles
1.
Taylor S, McWhirter R, Matlock B, Flaherty D, Miller 3rd D
STAR Protoc
. 2024 Nov;
5(4):103439.
PMID: 39514392
The C. elegans nervous system is compact and well described, ideal for identifying genetic programs that drive neuron-specific development, function, and connectivity. Here, we present a protocol for isolating specific...
2.
Natri H, Del Azodi C, Peter L, Taylor C, Chugh S, Kendle R, et al.
Nat Genet
. 2024 Apr;
56(5):1034.
PMID: 38664563
No abstract available.
3.
Natri H, Del Azodi C, Peter L, Taylor C, Chugh S, Kendle R, et al.
Nat Genet
. 2024 Mar;
56(4):595-604.
PMID: 38548990
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding...
4.
Natri H, Del Azodi C, Peter L, Taylor C, Chugh S, Kendle R, et al.
bioRxiv
. 2023 Mar;
PMID: 36993211
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis (PF). Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for...
5.
Pham L, Komalavilas P, Eddie A, Thayer T, Greenwood D, Liu K, et al.
Commun Biol
. 2022 Dec;
5(1):1366.
PMID: 36513703
Cellular metabolism influences immune cell function, with mitochondrial fatty acid β-oxidation and oxidative phosphorylation required for multiple immune cell phenotypes. Carnitine palmitoyltransferase 1a (Cpt1a) is considered the rate-limiting enzyme for...
6.
Patrick A, Shoaff K, Esmond T, Patrick D, Flaherty D, Graham T, et al.
Front Immunol
. 2022 Jul;
13:848168.
PMID: 35860254
In juvenile idiopathic arthritis (JIA) inflammatory T cells and their produced cytokines are drug targets and play a role in disease pathogenesis. Despite their clinical importance, the sources and types...
7.
Florian A, Woodley C, Wang J, Grieb B, Slota M, Guerrazzi K, et al.
NAR Cancer
. 2022 Mar;
4(1):zcac007.
PMID: 35252869
Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of , which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of is associated with a...
8.
Siladi A, Wang J, Florian A, Thomas L, Creighton J, Matlock B, et al.
Sci Rep
. 2022 Feb;
12(1):1848.
PMID: 35115608
WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule...
9.
Woodley C, Romer A, Wang J, Guarnaccia A, Elion D, Maxwell J, et al.
Oncogene
. 2021 May;
40(20):3593-3609.
PMID: 33931740
The SNF5 subunit of the SWI/SNF chromatin remodeling complex has been shown to act as a tumor suppressor through multiple mechanisms, including impairing the ability of the oncoprotein transcription factor...
10.
Saunders D, Aamodt K, Richardson T, Hopkirk A, Aramandla R, Poffenberger G, et al.
NPJ Regen Med
. 2021 Apr;
6(1):22.
PMID: 33824346
Endogenous β cell regeneration could alleviate diabetes, but proliferative stimuli within the islet microenvironment are incompletely understood. We previously found that β cell recovery following hypervascularization-induced β cell loss involves...