Brian C Grieb
Overview
Explore the profile of Brian C Grieb including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
279
Followers
0
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Recent Articles
1.
Meyer C, Smith B, Wang J, Teuscher K, Grieb B, Howard G, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2408889121.
PMID: 39167600
WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene expression. WDR5 is tethered to chromatin...
2.
Howard G, Wang J, L Rose K, Jones C, Patel P, Tsui T, et al.
Elife
. 2024 Apr;
12.
PMID: 38682900
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the 'WIN' site...
3.
Howard G, Wang J, Rose K, Jones C, Patel P, Tsui T, et al.
bioRxiv
. 2023 Aug;
PMID: 37546802
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the "WIN" site...
4.
Couwenberg A, Varvoglis D, Grieb B, Marijnen C, Ciombor K, Guillem J
Am Soc Clin Oncol Educ Book
. 2023 Jun;
43:e389558.
PMID: 37307515
Advances in multimodal management of locally advanced rectal cancer (LARC), consisting of preoperative chemotherapy and/or radiotherapy followed by surgery with or without adjuvant chemotherapy, have improved local disease control and...
5.
Teuscher K, Chowdhury S, Meyers K, Tian J, Sai J, Van Meveren M, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2211297120.
PMID: 36574664
WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of...
6.
Grieb B, Eischen C
Biology (Basel)
. 2022 Jun;
11(6).
PMID: 35741402
The oncogenic transcription factor c-MYC (MYC) is highly conserved across species and is frequently overexpressed or dysregulated in human cancers. MYC regulates a wide range of critical cellular and oncogenic...
7.
Florian A, Woodley C, Wang J, Grieb B, Slota M, Guerrazzi K, et al.
NAR Cancer
. 2022 Mar;
4(1):zcac007.
PMID: 35252869
Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of , which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of is associated with a...
8.
HER2-Directed Therapy in Advanced Gastric and Gastroesophageal Adenocarcinoma: Triumphs and Troubles
Grieb B, Agarwal R
Curr Treat Options Oncol
. 2021 Aug;
22(10):88.
PMID: 34424404
Gastric and gastroesophageal junction (GEJ) cancers represent the third leading cause of malignancy-associated death worldwide. Approximately 15-20% of these adenocarcinomas overexpress the human epidermal growth factor receptor 2 (HER2), a...
9.
Grieb B, Goff L, Goyal L, Denlinger C
Am Soc Clin Oncol Educ Book
. 2019 May;
39:248-260.
PMID: 31099615
The incidence and death rates of hepatocellular carcinoma (HCC) are rising. For more than a decade, the multikinase inhibitor sorafenib was the only U.S. Food and Drug Administration (FDA)-approved systemic...
10.
Grieb B, Boyd K, Mitra R, Eischen C
Aging (Albany NY)
. 2016 Nov;
8(10):2590-2602.
PMID: 27803394
Alterations of specific genes can modulate aging. Myc, a transcription factor that regulates the expression of many genes involved in critical cellular functions was shown to have a role in...