Gregg L Semenza
Overview
Explore the profile of Gregg L Semenza including associated specialties, affiliations and a list of published articles.
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337
Citations
43325
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Recent Articles
1.
Sharma D, Lau E, Qin Y, Jee K, Rodrigues M, Guo C, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(46):e2322759121.
PMID: 39499641
Neovascular age-related macular degeneration (nvAMD) is the leading cause of severe vision loss in the elderly in the developed world. While the introduction of therapies targeting vascular endothelial growth factor...
2.
Vaupel P, Semenza G
Adv Exp Med Biol
. 2024 Oct;
1463:15-20.
PMID: 39400793
On the occasion of ISOTT's half-century, in this chapter, tumour hypoxia (i.e. critically reduced oxygen levels on macro- and microscopic scales), recently classified as an additional hallmark of cancer, its...
3.
Gilkes D, Chaturvedi P, Bajpai S, Wong C, Wei H, Pitcairn S, et al.
Cancer Res
. 2024 Sep;
84(17):2927.
PMID: 39228257
No abstract available.
4.
Samanta D, Park Y, Andrabi S, Shelton L, Gilkes D, Semenza G
Cancer Res
. 2024 Sep;
84(17):2926.
PMID: 39228256
No abstract available.
5.
Walter Jackson Iii , Yang Y, Salman S, Dordai D, Lyu Y, Datan E, et al.
Sci Adv
. 2024 Aug;
10(35):eadq2366.
PMID: 39196939
Adoptive cell transfer (ACT) is a therapeutic strategy to augment antitumor immunity. Here, we report that ex vivo treatment of mouse CD8 T cells with dimethyloxalylglycine (DMOG), a stabilizer of...
6.
Lyu Y, Yang Y, Talwar V, Lu H, Chen C, Salman S, et al.
Cell Rep
. 2024 Mar;
43(4):113972.
PMID: 38517892
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates cellular adaptation to decreased oxygen availability. HIF-1 recruits chromatin-modifying enzymes leading to changes in histone acetylation, citrullination, and methylation at...
7.
8.
Gilkes D, Bajpai S, Wong C, Chaturvedi P, Hubbi M, Wirtz D, et al.
Mol Cancer Res
. 2023 Oct;
21(10):1120.
PMID: 37779464
No abstract available.
9.
Semenza G
Stem Cells Transl Med
. 2023 Sep;
12(12):783-790.
PMID: 37768037
Many advanced human cancers contain regions of intratumoral hypoxia, with O2 gradients extending to anoxia. Hypoxia-inducible factors (HIFs) are activated in hypoxic cancer cells and drive metabolic reprogramming, vascularization, invasion,...
10.
Semenza G
Semin Cancer Biol
. 2023 Sep;
96:5-10.
PMID: 37717718
Cancers express a large battery of genes by which they establish an immunosuppressive tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through transcriptional activation mediated by hypoxia-inducible...