Greg M Delgoffe
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Explore the profile of Greg M Delgoffe including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Carreno-Florez G, Kocak B, Hendricks M, Melvin J, Mar K, Kosanovich J, et al.
PLoS Pathog
. 2023 Nov;
19(11):e1011719.
PMID: 37939149
Clinical studies report that viral infections promote acute or chronic bacterial infections at multiple host sites. These viral-bacterial co-infections are widely linked to more severe clinical outcomes. In experimental models...
12.
DePeaux K, Delgoffe G
Trends Cancer
. 2023 Oct;
10(2):135-146.
PMID: 37880008
Oncolytic viruses (OVs), viruses engineered to lyse tumor cells, work hand in hand with the immune response. While for decades the field isolated lytic capability and viral spread to increase...
13.
Lane S, White T, Walsh E, Cattley R, Cumberland R, Hawse W, et al.
mBio
. 2023 Sep;
14(5):e0086323.
PMID: 37772820
Miscommunication of antiviral and antibacterial immune signals drives worsened morbidity and mortality during respiratory viral-bacterial coinfections. Extracellular vesicles (EVs) are a form of intercellular communication with broad implications during infection,...
14.
DePeaux K, Rivadeneira D, Lontos K, Dean V, Gunn W, Watson M, et al.
J Exp Med
. 2023 Aug;
220(10).
PMID: 37552475
While checkpoint blockade immunotherapies have widespread success, they rely on a responsive immune infiltrate; as such, treatments enhancing immune infiltration and preventing immunosuppression are of critical need. We previously generated...
15.
Augustin R, Huang Z, Ding F, Zhai S, McArdle J, Santisi A, et al.
Front Oncol
. 2023 Jul;
13:1075823.
PMID: 37397389
Background: Pre-clinical studies have shown that metformin reduces intratumoral hypoxia, improves T-cell function, and increases sensitivity to PD-1 blockade, and metformin exposure has been associated with improved clinical outcomes in...
16.
Burr A, Ji J, Ozler K, Mentrup H, Eskiocak O, Yueh B, et al.
Cell Mol Gastroenterol Hepatol
. 2023 May;
16(2):287-316.
PMID: 37172822
Background & Aims: The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit-amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage. The diet...
17.
18.
Scheff N, Nilsen M, Li J, Harris A, Acharya R, Swartz A, et al.
Oral Oncol
. 2023 Mar;
140:106363.
PMID: 36963232
Objectives: Head and neck squamous cell carcinoma (HNSCC) causes severe pain and opioids, the mainstay of pain management, may have immunomodulatory effects. We evaluated the effect of opioids on immunotherapy...
19.
Lontos K, Wang Y, Joshi S, Frisch A, Watson M, Kumar A, et al.
J Immunother Cancer
. 2023 Mar;
11(3).
PMID: 36914208
Background: Cellular immunotherapies for cancer represent a means by which a patient's immune system can be augmented with high numbers of tumor-specific T cells. Chimeric antigen receptor (CAR) therapy involves...
20.
Ayoob J, Boyce R, Livshits S, Bruno T, Delgoffe G, Galson D, et al.
J STEM Outreach
. 2023 Mar;
5(2).
PMID: 36910569
The University of Pittsburgh Medical Center Hillman Cancer Center Academy (Hillman Academy) has the primary goal of reaching high school students from underrepresented and disadvantaged backgrounds and guiding them through...