Amanda C Poholek
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Explore the profile of Amanda C Poholek including associated specialties, affiliations and a list of published articles.
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45
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3563
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Recent Articles
1.
Frisch A, Wang Y, Xie B, Yang A, Ford B, Joshi S, et al.
Cell Metab
. 2025 Jan;
PMID: 39879981
Cellular therapies are living drugs whose efficacy depends on persistence and survival. Expansion of therapeutic T cells employs hypermetabolic culture conditions to promote T cell expansion. We show that typical...
2.
Giri S, Poholek A
Immunity
. 2024 Dec;
57(12):2710-2712.
PMID: 39662085
Despite protective roles in various type of infection and in would healing, T helper (Th)2 cells are drivers of inflammation in allergic asthma. In this issue of Immunity, Zou et ...
3.
Qiu X, Yang A, Poholek A
Cancer Res
. 2024 Nov;
85(2):200-202.
PMID: 39589772
T-cell exhaustion remains a significant barrier to immunotherapeutic success for many patients with solid tumors. Growing evidence suggests that enhanced survival and self-renewal properties of a stem-like precursor T-cell population...
4.
Peralta R, Xie B, Lontos K, Nieves-Rosado H, Spahr K, Joshi S, et al.
Nat Immunol
. 2024 Nov;
25(12):2297-2307.
PMID: 39516648
CD8 T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell exhaustion, after persistent T cell receptor stimulation in the tumor microenvironment...
5.
He K, Xiao H, MacDonald W, Mehta I, Kishore A, Vincent A, et al.
Nat Immunol
. 2024 Oct;
25(11):2124-2139.
PMID: 39394532
The mechanisms that guide T helper 2 (T2) cell differentiation in barrier tissues are unclear. Here we describe the molecular pathways driving allergen-specific T2 cells using temporal, spatial and single-cell...
6.
Braverman E, Qin M, Schuler H, Brown H, Wittmann C, Ramgopal A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386600
Background: Chimeric antigen receptor T cell (CART) therapy has seen great clinical success. However, up to 50% of leukemia patients relapse and long-term survivor data indicate that CART cell persistence...
7.
Yang A, Poholek A
NPJ Syst Biol Appl
. 2024 Oct;
10(1):117.
PMID: 39384819
T cells are dynamically regulated immune cells that are implicated in a variety of diseases ranging from infection, cancer and autoimmunity. Recent advancements in sequencing methods have provided valuable insights...
8.
Zhao C, Xu Z, Wang X, Tao S, MacDonald W, He K, et al.
Brief Bioinform
. 2024 Mar;
25(2).
PMID: 38436557
Spatial transcriptomics technologies have shed light on the complexities of tissue structures by accurately mapping spatial microenvironments. Nonetheless, a myriad of methods, especially those utilized in platforms like Visium, often...
9.
Rahimikollu J, Xiao H, Rosengart A, Rosen A, Tabib T, Zdinak P, et al.
Nat Methods
. 2024 Feb;
21(5):835-845.
PMID: 38374265
Modern multiomic technologies can generate deep multiscale profiles. However, differences in data modalities, multicollinearity of the data, and large numbers of irrelevant features make analyses and integration of high-dimensional omic...
10.
Taylor T, Coleman B, Arunkumar S, Dey I, Dillon J, Ponde N, et al.
Cell Host Microbe
. 2023 Sep;
31(10):1700-1713.e4.
PMID: 37725983
Fungal infections are a global threat; yet, there are no licensed vaccines to any fungal pathogens. Th17 cells mediate immunity to Candida albicans, particularly oropharyngeal candidiasis (OPC), but essential downstream...