Nicole E Scharping
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Explore the profile of Nicole E Scharping including associated specialties, affiliations and a list of published articles.
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21
Citations
2277
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Recent Articles
1.
Reina-Campos M, Monell A, Ferry A, Luna V, Cheung K, Galletti G, et al.
Nature
. 2025 Jan;
639(8054):483-492.
PMID: 39843748
Tissue-resident memory CD8 T (T) cells provide protection from infection at barrier sites. In the small intestine, T cells are found in at least two distinct subpopulations: one with higher...
2.
Ferry A, Mempel K, Monell A, Reina-Campos M, Scharping N, Heeg M, et al.
J Exp Med
. 2025 Jan;
222(2.
PMID: 39841133
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that...
3.
Reina-Campos M, Monell A, Ferry A, Luna V, Cheung K, Galletti G, et al.
bioRxiv
. 2024 Apr;
PMID: 38585842
Tissue-resident memory CD8 T cells (T) kill infected cells and recruit additional immune cells to limit pathogen invasion at barrier sites. Small intestinal (SI) T cells consist of distinct subpopulations...
4.
Alvarez-Breckenridge C, Anderson K, Correia A, Demehri S, Dinh H, Dixon K, et al.
Cancer Immunol Res
. 2023 Oct;
11(12):1571-1577.
PMID: 37906619
The Arthur and Sandra Irving Cancer Immunology Symposium has been created as a platform for established cancer immunologists to mentor trainees and young investigators as they launch their research career...
5.
Vignali P, DePeaux K, Watson M, Ye C, Ford B, Lontos K, et al.
Nat Immunol
. 2022 Dec;
24(2):267-279.
PMID: 36543958
CD8 T cells are critical for elimination of cancer cells. Factors within the tumor microenvironment (TME) can drive these cells to a hypofunctional state known as exhaustion. The most terminally...
6.
Ford B, Vignali P, Rittenhouse N, Scharping N, Peralta R, Lontos K, et al.
Sci Immunol
. 2022 Aug;
7(74):eabj9123.
PMID: 35930654
Response rates to immunotherapy in solid tumors remain low due in part to the elevated prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced through persistent antigen and...
7.
Jacobs H, Arkatkar T, Du S, Scharping N, Woods J, Li Q, et al.
Eur J Immunol
. 2021 Jun;
51(9):2225-2236.
PMID: 34146342
Polymorphisms in TACI, a BAFF family cytokine receptor, are linked to diverse human immune disorders including common variable immunodeficiency (CVID) and systemic lupus erythematosus (SLE). Functional studies of individual variants...
8.
Milner J, Toma C, Quon S, Omilusik K, Scharping N, Dey A, et al.
J Exp Med
. 2021 May;
218(8).
PMID: 34037670
In response to infection, pathogen-specific CD8 T cells differentiate into functionally diverse effector and memory T cell populations critical for resolving disease and providing durable immunity. Through small-molecule inhibition, RNAi...
9.
Reina-Campos M, Scharping N, Goldrath A
Nat Rev Immunol
. 2021 May;
21(11):718-738.
PMID: 33981085
Cytotoxic CD8 T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8 T...
10.
Liikanen I, Lauhan C, Quon S, Omilusik K, Phan A, Bartroli L, et al.
J Clin Invest
. 2021 Apr;
131(7).
PMID: 33792560
Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall response rates in patients with solid tumors underscore remaining challenges in realizing the potential of this...