Greg Donahue
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Explore the profile of Greg Donahue including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Egervari G, Donahue G, Carde N, Alexander D, Hogan C, Shaw J, et al.
Neuropharmacology
. 2024 Dec;
265:110258.
PMID: 39653249
Metabolic-epigenetic interactions are emerging as key pathways in regulating alcohol-related transcriptional changes in the brain. Recently, we have shown that this is mediated by the metabolic enzyme Acetyl-CoA synthetase 2...
2.
Zhang J, Donahue G, Gilbert M, Lapidot T, Nicetto D, Zaret K
Nat Cell Biol
. 2024 Nov;
26(12):2115-2128.
PMID: 39482359
H3K9me3 heterochromatin, established by lysine methyltransferases (KMTs) and compacted by heterochromatin protein 1 (HP1) isoforms, represses alternative lineage genes and DNA repeats. Our understanding of H3K9me3 heterochromatin stability is presently...
3.
Zhang J, Donahue G, Gilbert M, Lapidot T, Nicetto D, Zaret K
bioRxiv
. 2024 Sep;
PMID: 39345615
H3K9me3-heterochromatin, established by lysine methyltransferases (KMTs) and compacted by HP1 isoforms, represses alternative lineage genes and DNA repeats. Our understanding of H3K9me3-heterochromatin stability is presently limited to individual domains and...
4.
Xu D, Sas-Nowosielska H, Donahue G, Huang H, Pourshafie N, Good C, et al.
Acta Neuropathol Commun
. 2024 Jan;
12(1):3.
PMID: 38167174
Alzheimer's Disease (AD) is a disorder characterized by cognitive decline, neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. Dysregulation of epigenetic histone modifications may lead...
5.
Sen P, Donahue G, Li C, Egervari G, Yang N, Lan Y, et al.
Nat Aging
. 2023 Apr;
3(4):402-417.
PMID: 37117791
Mammalian aging is characterized by the progressive loss of tissue function and increased risk for disease. Accumulation of senescent cells in aging tissues partly contributes to this decline, and targeted...
6.
Frederick M, Williamson K, Garcia M, Ferretti M, McCarthy R, Donahue G, et al.
Nat Struct Mol Biol
. 2022 Dec;
30(1):31-37.
PMID: 36536103
To determine how different pioneer transcription factors form a targeted, accessible nucleosome within compacted chromatin and collaborate with an ATP-dependent chromatin remodeler, we generated nucleosome arrays in vitro with a...
7.
Mendoza M, Egervari G, Sidoli S, Donahue G, Alexander D, Sen P, et al.
Sci Adv
. 2022 Jan;
8(3):eabj5688.
PMID: 35061542
Histone acetylation is governed by nuclear acetyl-CoA pools generated, in part, from local acetate by metabolic enzyme acetyl-CoA synthetase 2 (ACSS2). We hypothesize that during gene activation, a local transfer...
8.
Good C, Aznar M, Kuramitsu S, Samareh P, Agarwal S, Donahue G, et al.
Cell
. 2021 Dec;
184(25):6081-6100.e26.
PMID: 34861191
Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell exhaustion in the...
9.
McCarthy R, Kaeding K, Keller S, Zhong Y, Xu L, Hsieh A, et al.
Nat Cell Biol
. 2021 Sep;
23(11):1212.
PMID: 34588637
No abstract available.
10.
Palozola K, Donahue G, Zaret K
STAR Protoc
. 2021 Sep;
2(3):100651.
PMID: 34485932
The protocol allows for labeling nascent RNA without isolating nuclei. The cell-permeable uridine analog, 5-ethynyluridine (EU), is added to media to allow labeling of nascent transcripts. Cells are lysed, total...