Granton A Jindal
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Explore the profile of Granton A Jindal including associated specialties, affiliations and a list of published articles.
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14
Citations
312
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Recent Articles
1.
Jindal G, Lim F, Tellez K, Song B, Bantle A, Farley E
STAR Protoc
. 2024 Jul;
5(3):103107.
PMID: 38963758
Electroporation is a technique to introduce DNA constructs into cells using electric current. Here, we present a protocol to electroporate DNA plasmids into Ciona robusta embryos at the 1-cell stage....
2.
Lim F, Solvason J, Ryan G, Le S, Jindal G, Steffen P, et al.
Nature
. 2024 Jan;
626(7997):151-159.
PMID: 38233525
Enhancers control the location and timing of gene expression and contain the majority of variants associated with disease. The ZRS is arguably the most well-studied vertebrate enhancer and mediates the...
3.
Jindal G, Bantle A, Solvason J, Grudzien J, DAntonio-Chronowska A, Lim F, et al.
Dev Cell
. 2023 Oct;
58(21):2206-2216.e5.
PMID: 37848026
Transcriptional enhancers direct precise gene expression patterns during development and harbor the majority of variants associated with phenotypic diversity, evolutionary adaptations, and disease. Pinpointing which enhancer variants contribute to changes...
4.
Song B, Ragsac M, Tellez K, Jindal G, Grudzien J, Le S, et al.
Cell Rep
. 2023 Feb;
42(2):112052.
PMID: 36729834
The notochord is a defining feature of all chordates. The transcription factors Zic and ETS regulate enhancer activity within the notochord. We conduct high-throughput screens of genomic elements within developing...
5.
Jindal G, Farley E
Dev Cell
. 2021 Mar;
56(5):575-587.
PMID: 33689769
Each language has standard books describing that language's grammatical rules. Biologists have searched for similar, albeit more complex, principles relating enhancer sequence to gene expression. Here, we review the literature...
6.
Marmion R, Yang L, Goyal Y, Jindal G, Wetzel J, Singh M, et al.
Mol Biol Cell
. 2021 Jan;
32(9):974-983.
PMID: 33476180
Terminal regions of embryos are patterned by signaling through ERK, which is genetically deregulated in multiple human diseases. Quantitative studies of terminal patterning have been recently used to investigate gain-of-function...
7.
Pelliccia J, Jindal G, Burdine R
Elife
. 2017 Nov;
6.
PMID: 29140250
Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; directs left-right asymmetries, while and function earlier to pattern mesendoderm. TGFβ...
8.
Jindal G, Goyal Y, Humphreys J, Yeung E, Tian K, Patterson V, et al.
J Biol Chem
. 2017 Oct;
292(46):18814-18820.
PMID: 29018093
The MEK1 kinase directly phosphorylates ERK2, after the activation loop of MEK1 is itself phosphorylated by Raf. Studies over the past decade have revealed a large number of disease-related mutations...
9.
Goyal Y, Jindal G, Pelliccia J, Yamaya K, Yeung E, Futran A, et al.
Nat Genet
. 2017 Feb;
49(3):465-469.
PMID: 28166211
Germline mutations in Ras pathway components are associated with a large class of human developmental abnormalities, known as RASopathies, that are characterized by a range of structural and functional phenotypes,...
10.
Jindal G, Goyal Y, Yamaya K, Futran A, Kountouridis I, Balgobin C, et al.
Proc Natl Acad Sci U S A
. 2017 Jan;
114(3):510-515.
PMID: 28049852
Germ-line mutations in components of the Ras/MAPK pathway result in developmental disorders called RASopathies, affecting about 1/1,000 human births. Rapid advances in genome sequencing make it possible to identify multiple...