Trudi Schupbach
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Explore the profile of Trudi Schupbach including associated specialties, affiliations and a list of published articles.
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63
Citations
2090
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Recent Articles
1.
Marmion R, Simpkins A, Barrett L, Denberg D, Zusman S, Schottenfeld-Roames J, et al.
Curr Biol
. 2023 Jan;
33(5):807-816.e4.
PMID: 36706752
Germline mutations upregulating RAS signaling are associated with multiple developmental disorders. A hallmark of these conditions is that the same mutation may present vastly different phenotypes in different individuals, even...
2.
Marmion R, Yang L, Goyal Y, Jindal G, Wetzel J, Singh M, et al.
Mol Biol Cell
. 2021 Jan;
32(9):974-983.
PMID: 33476180
Terminal regions of embryos are patterned by signaling through ERK, which is genetically deregulated in multiple human diseases. Quantitative studies of terminal patterning have been recently used to investigate gain-of-function...
3.
Merkle J, Wittes J, Schupbach T
Curr Top Dev Biol
. 2020 Jun;
140:55-86.
PMID: 32591083
In Drosophila, specification of the embryonic body axes requires signaling between the germline and the somatic follicle cells. These signaling events are necessary to properly localize embryonic patterning determinants in...
4.
Schupbach T
Annu Rev Genet
. 2019 Dec;
53:1-18.
PMID: 31794267
In development, the axes of the egg and future embryo are established during oogenesis. To learn about the underlying genetic and molecular pathways that lead to axis formation, I conducted...
5.
Wittes J, Schupbach T
G3 (Bethesda)
. 2018 Nov;
9(1):47-60.
PMID: 30385460
The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) and epidermal growth factor receptor (EGFR) signaling pathways are conserved regulators of tissue patterning, morphogenesis, and other cell biological processes. During...
6.
Goyal Y, Schupbach T, Shvartsman S
Dev Biol
. 2018 Jul;
442(1):80-86.
PMID: 30026122
Receptor tyrosine kinases (RTKs) control a wide range of developmental processes, from the first stages of embryogenesis to postnatal growth and neurocognitive development in the adult. A significant share of...
7.
Pritykin Y, Brito T, Schupbach T, Singh M, Pane A
RNA
. 2017 Apr;
23(7):1097-1109.
PMID: 28420675
Piwi-interacting RNAs (piRNAs) are central components of the piRNA pathway, which directs transposon silencing and guarantees genome integrity in the germ cells of several metazoans. In , piRNAs are produced...
8.
Schupbach T, Wieschaus E
Rouxs Arch Dev Biol
. 2017 Mar;
195(5):302-317.
PMID: 28306055
Mutations in seven different maternal-effect loci on the second chromosome of Drosophila melanogaster all cause alterations in the anterior-posterior pattern of the embryo. Mutations in torso (tor) and trunk (trk)...
9.
Schupbach T, Wieschaus E, Nothiger R
Wilehm Roux Arch Dev Biol
. 2017 Mar;
184(1):41-56.
PMID: 28305012
Our report presents an analysis of the development and dynamics of the female germ line inDrosophila. Females were produced that were mosaic either for attached-X chromosomes[Formula: see text] and a...
10.
Schupbach T, Wieschaus E, Nothiger R
Wilehm Roux Arch Dev Biol
. 2017 Mar;
185(3):249-270.
PMID: 28304991
The embryonic organization of the sexually dimorphic genital disc was studied in genetic mosaics resulting (a) from early loss of a chromosome or (b) from mitotic recombination. (a) Early Loss...