Grant S Stewart
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Explore the profile of Grant S Stewart including associated specialties, affiliations and a list of published articles.
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88
Citations
3441
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Recent Articles
11.
Nieminuszczy J, Martin P, Broderick R, Krwawicz J, Kanellou A, Mocanu C, et al.
Nucleic Acids Res
. 2023 May;
51(12):6337-6354.
PMID: 37224534
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress (RS) and protect replication...
12.
Patel P, Algouneh A, Krishnan R, Reynolds J, Nixon K, Hao J, et al.
Nucleic Acids Res
. 2023 Mar;
51(9):4341-4362.
PMID: 36928661
BRCA1 mutations are associated with increased breast and ovarian cancer risk. BRCA1-mutant tumors are high-grade, recurrent, and often become resistant to standard therapies. Herein, we performed a targeted CRISPR-Cas9 screen...
13.
Datta A, Sommers J, Jhujh S, Harel T, Stewart G, Brosh Jr R
Ageing Res Rev
. 2023 Feb;
86:101887.
PMID: 36805074
Characterizing the molecular deficiencies underlying human aging has been a formidable challenge as it is clear that a complex myriad of factors including genetic mutations, environmental influences, and lifestyle choices...
14.
Fletcher S, Hall C, Kennedy T, Pajusalu S, Wojcik M, Boora U, et al.
J Clin Invest
. 2023 Feb;
133(7.
PMID: 36795492
Although protein hydroxylation is a relatively poorly characterized posttranslational modification, it has received significant recent attention following seminal work uncovering its role in oxygen sensing and hypoxia biology. Although the...
15.
Serey-Gaut M, Cortes M, Makrythanasis P, Suri M, Taylor A, Sullivan J, et al.
Am J Hum Genet
. 2023 Feb;
110(3):499-515.
PMID: 36724785
Telomere maintenance 2 (TELO2), Tel2 interacting protein 2 (TTI2), and Tel2 interacting protein 1 (TTI1) are the three components of the conserved Triple T (TTT) complex that modulates activity of...
16.
Nieminuszczy J, Martin P, Broderick R, Krwawicz J, Kanellou A, Mocanu C, et al.
bioRxiv
. 2023 Jan;
PMID: 36711944
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress (RS) and protect replication...
17.
Grange L, Reynolds J, Ullah F, Isidor B, Shearer R, Latypova X, et al.
Nat Commun
. 2022 Nov;
13(1):6664.
PMID: 36333305
Embryonic development is dictated by tight regulation of DNA replication, cell division and differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving rise to neurodevelopmental disease characterized...
18.
Bayley R, Borel V, Moss R, Sweatman E, Ruis P, Ormrod A, et al.
Mol Cell
. 2022 Apr;
82(10):1924-1939.e10.
PMID: 35439434
The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 interacts with damaged chromatin via phospho-53BP1 and facilitates recruitment of the...
19.
Lappin K, Barros E, Jhujh S, Irwin G, McMillan H, Liberante F, et al.
Cancer Res
. 2022 Jan;
82(5):819-830.
PMID: 35027467
Significance: The cancer-associated SF3B1K700E mutation induces DNA damage via generation of genotoxic R-loops and stalled replication forks, defective homologous recombination, and increased replication fork degradation, which can be targeted with...
20.
Abu-Libdeh B, Jhujh S, Dhar S, Sommers J, Datta A, Longo G, et al.
J Clin Invest
. 2022 Jan;
132(5).
PMID: 35025765
Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of the human RECQ...