Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

Overview

Journal Cancer Res

Specialty Oncology

Date 2022 Jan 14

PMID 35027467

Authors

Katrina M Lappin

Eliana M Barros

Satpal S Jhujh

Gareth W Irwin

Hayley McMillan

Fabio G Liberante

Cheryl Latimer

Melissa J La Bonte

Ken I Mills

D Paul Harkin

Grant S Stewart

Kienan I Savage

Affiliations

Soon will be listed here.

Abstract

Significance: The cancer-associated SF3B1K700E mutation induces DNA damage via generation of genotoxic R-loops and stalled replication forks, defective homologous recombination, and increased replication fork degradation, which can be targeted with PARP inhibitors.

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