Johan W M Heemskerk
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Explore the profile of Johan W M Heemskerk including associated specialties, affiliations and a list of published articles.
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226
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5301
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Recent Articles
1.
Martinez-Botia P, Yunga S, Szklanna P, Babur O, Emili A, Wilmarth P, et al.
J Thromb Haemost
. 2025 Feb;
PMID: 39952361
Over the past 3 decades, omics technologies have revolutionized our understanding of platelet molecular content and organization, enabling the systematic analyses of platelet physiology. Among these approaches, proteomics has been...
2.
Swieringa F, Heemskerk J, Assinger A
Blood
. 2025 Jan;
PMID: 39869836
In thrombosis and hemostasis, the formation of a platelet-fibrin thrombus or clot is a highly controlled process that varies, depending on the pathological context. Major signaling pathways in platelets are...
3.
Loroch S, Panagiotidis E, Klewe K, Swieringa F, Heemskerk J, Heemskerk J, et al.
Thromb Haemost
. 2025 Jan;
PMID: 39814053
Comprehensive characterization of platelets requires various functional assays and analytical techniques, including omics disciplines, each demanding a separate aliquot of the given sample. Consequently, sample material for each assay is...
4.
Schonichen C, Sun S, Middelveld H, Huskens D, de Groot P, Heemskerk J, et al.
Thromb Res
. 2024 Nov;
244:109208.
PMID: 39522336
Antithrombin and tissue factor pathway inhibitor (TFPI) provide different anticoagulant mechanisms. Having established a potent anticoagulant role of cultured human umbilical vein endothelial cells in vessel-on-a-chip microfluidic models, we now...
5.
Zou J, Zhang P, Solari F, Schonichen C, Provenzale I, Mattheij N, et al.
J Biol Chem
. 2024 Oct;
300(12):107899.
PMID: 39424145
Agonist-induced rises in cytosolic Ca control most platelet responses in thrombosis and hemostasis. In human platelets, we earlier demonstrated that the ORAI1-STIM1 pathway is a major component of extracellular Ca...
6.
Zou J, Sun S, de Simone I, Ten Cate H, de Groot P, de Laat B, et al.
TH Open
. 2024 Jun;
8(2):e232-e242.
PMID: 38911141
Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation. The signaling...
7.
Singh A, Kraaijeveld A, Curaj A, Wichapong K, Hammerich L, de Jager S, et al.
Front Immunol
. 2024 May;
15:1327051.
PMID: 38807599
Introduction: The CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes...
8.
Zhang P, von Ungern-Sternberg S, Hastenplug L, Solari F, Sickmann A, Kuijpers M, et al.
Thromb Haemost
. 2024 Apr;
PMID: 38653482
Background: Platelet glycoprotein VI (GPVI) stimulation activates the tyrosine kinases Syk and Btk, and the effector proteins phospholipase Cγ 2 (PLCγ2) and protein kinase C (PKC). Here, the activation sequence,...
9.
Melo S, Nondonfaz A, Aqil A, Pierrard A, Hulin A, Delierneux C, et al.
Biomater Sci
. 2024 Mar;
12(8):2149-2164.
PMID: 38487997
The sole effective treatment for most patients with heart valve disease is valve replacement by implantation of mechanical or biological prostheses. However, mechanical valves represent high risk of thromboembolism, and...
10.
Fernandez D, Troitino S, Sobota V, Tullemans B, Zou J, van den Hurk H, et al.
Sci Rep
. 2024 Mar;
14(1):6229.
PMID: 38486006
Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin. This is reflected in the different...