Gernot Wolf
Overview
Explore the profile of Gernot Wolf including associated specialties, affiliations and a list of published articles.
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22
Citations
502
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Recent Articles
1.
Li H, Pike A, Chang Y, Prakaash D, Gelova Z, Stanka J, et al.
Nat Commun
. 2025 Jan;
16(1):721.
PMID: 39820269
Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects....
2.
Wolf G, Craigon C, Teoh S, Essletzbichler P, Onstein S, Cassidy D, et al.
Cell Chem Biol
. 2025 Jan;
32(2):291-306.e6.
PMID: 39755121
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting "undruggable"...
3.
Ferdigg A, Hopp A, Wolf G, Superti-Furga G
Life Sci Alliance
. 2024 Nov;
8(2).
PMID: 39578074
Non-essential metals are extremely toxic to living organisms, posing significant health risks, particularly in developing nations where they are a major contributor to illness and death. Although their toxicity is...
4.
Jin J, Ralls S, Wu E, Wolf G, Sun M, Springer D, et al.
bioRxiv
. 2024 Aug;
PMID: 39185186
Mammalian brains are larger and more densely packed with neurons than reptiles, but the genetic mechanisms underlying the increased connection complexity amongst neurons are unclear. The expression diversity of clustered...
5.
Santacruz D, Enane F, Fundel-Clemens K, Giner M, Wolf G, Onstein S, et al.
SLAS Discov
. 2024 Jun;
29(5):100169.
PMID: 38897875
No abstract available.
6.
Gelova Z, Ingles-Prieto A, Bohstedt T, Frommelt F, Chi G, Chang Y, et al.
J Mol Biol
. 2024 Jun;
436(16):168665.
PMID: 38878854
Transporters of the solute carrier superfamily (SLCs) are responsible for the transmembrane traffic of the majority of chemical substances in cells and tissues and are therefore of fundamental biological importance....
7.
Azzollini L, Prete D, Wolf G, Klimek C, Saggioro M, Ricci F, et al.
SLAS Discov
. 2024 Jun;
29(5):100166.
PMID: 38848895
Zinc is an essential trace element that is involved in many biological processes and in cellular homeostasis. In pancreatic β-cells, zinc is crucial for the synthesis, processing, and secretion of...
8.
Sijben H, Dall Acqua L, Liu R, Jarret A, Christodoulaki E, Onstein S, et al.
Front Pharmacol
. 2022 Jun;
13:872335.
PMID: 35677430
Excitatory amino acid transporters (EAAT/SLC1) mediate Na-dependent uptake of extracellular glutamate and are potential drug targets for neurological disorders. Conventional methods to assess glutamate transport are based on radiolabels, fluorescent...
9.
Santacruz D, Enane F, Fundel-Clemens K, Giner M, Wolf G, Onstein S, et al.
SLAS Discov
. 2022 Jan;
27(2):140-147.
PMID: 35093290
Over the last decade, whole transcriptome profiling, also known as RNA-sequencing (RNA-seq), has quickly gained traction as a reliable method for unbiased assessment of gene expression. Integration of RNA-seq expression...
10.
Sun M, Wolf G, Wang Y, Senft A, Ralls S, Jin J, et al.
Mol Biol Evol
. 2021 Jul;
38(11):4992-5004.
PMID: 34320657
In mammals, the placenta mediates maternal-fetal nutrient and waste exchange and acts in an immunomodulatory way to facilitate maternal-fetal tolerance. The placenta is highly diverse across mammalian species, yet the...