Gerard H M Huysmans
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Explore the profile of Gerard H M Huysmans including associated specialties, affiliations and a list of published articles.
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21
Citations
304
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Recent Articles
1.
Ciftci D, Martens C, Ghani V, Blanchard S, Politis A, Huysmans G, et al.
Proc Natl Acad Sci U S A
. 2021 Dec;
118(49).
PMID: 34873050
Transporters cycle through large structural changes to translocate molecules across biological membranes. The temporal relationships between these changes and function, and the molecular properties setting their rates, determine transport efficiency-yet...
2.
Ciftci D, Huysmans G, Wang X, He C, Terry D, Zhou Z, et al.
Bio Protoc
. 2021 Apr;
11(7):e3970.
PMID: 33889664
Secondary active transporters reside in cell membranes transporting polar solutes like amino acids against steep concentration gradients, using electrochemical gradients of ions as energy sources. Commonly, ensemble-based measurements of radiolabeled...
3.
Huysmans G, Marx D, Radford S, Fleming K
Methods Mol Biol
. 2021 Feb;
2168:217-232.
PMID: 33582994
The thermodynamic stabilities of membrane proteins are of fundamental interest to provide a biophysical description of their structure-function relationships because energy determines conformational populations. In addition, structure-energy relationships can be...
4.
Huysmans G, Ciftci D, Wang X, Blanchard S, Boudker O
EMBO J
. 2020 Nov;
40(1):e105415.
PMID: 33185289
Membrane transporters mediate cellular uptake of nutrients, signaling molecules, and drugs. Their overall mechanisms are often well understood, but the structural features setting their rates are mostly unknown. Earlier single-molecule...
5.
Matin T, Heath G, Huysmans G, Boudker O, Scheuring S
Nat Commun
. 2020 Oct;
11(1):5016.
PMID: 33024106
Excitatory amino acid transporters (EAATs) are important in many physiological processes and crucial for the removal of excitatory amino acids from the synaptic cleft. Here, we develop and apply high-speed...
6.
Ciftci D, Huysmans G, Wang X, He C, Terry D, Zhou Z, et al.
Sci Adv
. 2020 Jun;
6(22):eaaz1949.
PMID: 32523985
Kinetic properties of membrane transporters are typically poorly defined because high-resolution functional assays analogous to single-channel recordings are lacking. Here, we measure single-molecule transport kinetics of a glutamate transporter homolog...
7.
Huang Y, Wang X, Lv G, Razavi A, Huysmans G, Weinstein H, et al.
Nat Chem Biol
. 2020 Jun;
16(9):1006-1012.
PMID: 32514183
In proteins where conformational changes are functionally important, the number of accessible states and their dynamics are often difficult to establish. Here we describe a novel F-NMR spectroscopy approach to...
8.
Yuan X, Johnson M, Zhang J, Lo A, Schembri M, Wijeyewickrema L, et al.
Nat Commun
. 2018 Apr;
9(1):1395.
PMID: 29643377
Bacterial autotransporters comprise a C-terminal β-barrel domain, which must be correctly folded and inserted into the outer membrane to facilitate translocation of the N-terminal passenger domain to the cell exterior....
9.
Guilvout I, Brier S, Chami M, Hourdel V, Francetic O, Pugsley A, et al.
J Biol Chem
. 2016 Dec;
292(1):328-338.
PMID: 27903652
Members of a group of multimeric secretion pores that assemble independently of any known membrane-embedded insertase in Gram-negative bacteria fold into a prepore before membrane-insertion occurs. The mechanisms and the...
10.
Huysmans G
Biochem Soc Trans
. 2016 Jun;
44(3):845-50.
PMID: 27284050
Since the discovery of the essential role of the β-barrel assembly machinery (BAM) for the membrane insertion of outer membrane proteins (OMPs) that are unrelated in sequence, members of this...