Gerard H M Huysmans
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Explore the profile of Gerard H M Huysmans including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
East A, Mechaly A, Huysmans G, Bernarde C, Tello-Manigne D, Nadeau N, et al.
Structure
. 2015 Dec;
24(1):92-104.
PMID: 26688215
The Klebsiella lipoprotein pullulanase (PulA) is exported to the periplasm, triacylated, and anchored via lipids in the inner membrane (IM) prior to its transport to the bacterial surface through a...
12.
Huysmans G, Guilvout I, Chami M, Nickerson N, Pugsley A
Sci Rep
. 2015 Oct;
5:15068.
PMID: 26463896
Like several other large, multimeric bacterial outer membrane proteins (OMPs), the assembly of the Klebsiella oxytoca OMP PulD does not rely on the universally conserved β-barrel assembly machinery (BAM) that...
13.
Leyton D, Johnson M, Thapa R, Huysmans G, Dunstan R, Celik N, et al.
Nat Commun
. 2014 Jun;
5:4239.
PMID: 24967730
Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines...
14.
Independent domain assembly in a trapped folding intermediate of multimeric outer membrane secretins
Guilvout I, Chami M, Disconzi E, Bayan N, Pugsley A, Huysmans G
Structure
. 2014 Mar;
22(4):582-9.
PMID: 24657091
The outer membrane portal of the Klebsiella oxytoca type II secretion system, PulD, is a prototype of a family of proteins, the secretins, which are essential components of many bacterial...
15.
Disconzi E, Guilvout I, Chami M, Masi M, Huysmans G, Pugsley A, et al.
J Bacteriol
. 2013 Oct;
196(1):121-8.
PMID: 24142256
Proteins called secretins form large multimeric complexes that are essential for macromolecular transit across the outer membrane of Gram-negative bacteria. Evidence suggests that the channels formed by some secretin complexes...
16.
Huysmans G, Guilvout I, Pugsley A
J Biol Chem
. 2013 Sep;
288(42):30700-30707.
PMID: 24019525
Investigations into protein folding are largely dominated by studies on monomeric proteins. However, the transmembrane domain of an important group of membrane proteins is only formed upon multimerization. Here, we...
17.
McMorran L, Bartlett A, Huysmans G, Radford S, Brockwell D
J Mol Biol
. 2013 Jun;
425(17):3178-91.
PMID: 23796519
Although many periplasmic folding factors have been identified, the mechanisms by which they interact with unfolded outer membrane proteins (OMPs) to promote correct folding and membrane insertion remain poorly understood....
18.
Huysmans G, Chan N, Baldwin J, Postis V, Tzokov S, Deacon S, et al.
Biochem J
. 2012 May;
445(2):157-66.
PMID: 22553922
Urea is exploited as a nitrogen source by bacteria, and its breakdown products, ammonia and bicarbonate, are employed to counteract stomach acidity in pathogens such as Helicobacter pylori. Uptake in...
19.
Huysmans G, Radford S, Baldwin S, Brockwell D
J Mol Biol
. 2012 Jan;
416(3):453-64.
PMID: 22245579
Understanding the interactions between membrane proteins and the lipid bilayer is key to increasing our ability to predict and tailor the folding mechanism, structure and stability of membrane proteins. Here,...
20.
Huysmans G, Baldwin S, Brockwell D, Radford S
Proc Natl Acad Sci U S A
. 2010 Feb;
107(9):4099-104.
PMID: 20133664
Inspired by the seminal work of Anfinsen, investigations of the folding of small water-soluble proteins have culminated in detailed insights into how these molecules attain and stabilize their native folds....