Georgina Berridge
Overview
Explore the profile of Georgina Berridge including associated specialties, affiliations and a list of published articles.
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30
Citations
730
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Recent Articles
1.
Jainarayanan A, Capera J, Cespedes P, Conceicao M, Elanchezhian M, Thomas T, et al.
J Extracell Biol
. 2024 Jun;
2(3):e74.
PMID: 38938417
CD8 T lymphocytes play vital roles in killing infected or deranged host cells, recruiting innate immune cells, and regulating other aspects of immune responses. Like any other cell, CD8 T...
2.
Mi Y, Burnham K, Charles P, Heilig R, Vendrell I, Whalley J, et al.
Sci Transl Med
. 2024 Jun;
16(750):eadh0185.
PMID: 38838133
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of pathophysiology and new therapeutic approaches. Here, we applied high-throughput tandem...
3.
Ayagama T, Charles P, Bose S, Boland B, Priestman D, Aston D, et al.
iScience
. 2024 Jun;
27(6):109609.
PMID: 38827406
Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL facilitate the elimination of damaged membranes, protein aggregates, membranous organelles and play an important role...
4.
Davies A, Lleixa C, Siles A, Gourlay D, Berridge G, Dejnirattisai W, et al.
Neurol Neuroimmunol Neuroinflamm
. 2022 Nov;
10(1).
PMID: 36411078
Background And Objectives: Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed...
5.
Cavounidis A, Pandey S, Capitani M, Friedrich M, Cross A, Gartner L, et al.
Mucosal Immunol
. 2022 Oct;
15(6):1431-1446.
PMID: 36302964
Hermansky-Pudlak syndrome (HPS) types 1 and 4 are caused by defective vesicle trafficking. The mechanism for Crohn's disease-like inflammation, lung fibrosis, and macrophage lipid accumulation in these patients remains enigmatic....
6.
Leissing T, Hardy A, Chan H, Wang Y, Tumber A, Chowdhury R, et al.
J Biol Chem
. 2022 May;
298(6):102020.
PMID: 35537551
The aspariginyl hydroxylase human factor inhibiting hypoxia-inducible factor (FIH) is an important regulator of the transcriptional activity of hypoxia-inducible factor. FIH also catalyzes the hydroxylation of asparaginyl and other residues...
7.
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Elliott P, Leske D, Wagstaff J, Schlicher L, Berridge G, Maslen S, et al.
Cell Rep
. 2021 Oct;
37(1):109777.
PMID: 34610306
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase...
8.
Ayagama T, Bose S, Capel R, Priestman D, Berridge G, Fischer R, et al.
iScience
. 2021 Sep;
24(9):102949.
PMID: 34466782
The importance of lysosomes in cardiac physiology and pathology is well established, and evidence for roles in calcium signaling is emerging. We describe a label-free proteomics method suitable for small...
9.
Harris L, Le Pen J, Scholz N, Mieszczanek J, Vaughan N, Davis S, et al.
J Biol Chem
. 2021 Apr;
296:100246.
PMID: 33853758
Ubiquitin is a versatile posttranslational modification, which is covalently attached to protein targets either as a single moiety or as a ubiquitin chain. In contrast to K48 and K63-linked chains,...
10.
Xavier M, Liu S, Bugge T, Torres J, Mosley M, Hopkins S, et al.
J Nucl Med
. 2019 Apr;
60(10):1474-1482.
PMID: 30954944
Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The wild-type protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form...