Opher Gileadi
Overview
Explore the profile of Opher Gileadi including associated specialties, affiliations and a list of published articles.
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Articles
95
Citations
3212
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Recent Articles
1.
Newman J, Gavard A, Imprachim N, Aitkenhead H, Sheppard H, Te Poele R, et al.
Nat Commun
. 2025 Feb;
16(1):1596.
PMID: 39952925
Brachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. Brachyury is minimally expressed...
2.
Bradshaw W, Harris G, Gileadi O, Katis V
Structure
. 2024 Oct;
32(12):2337-2351.e4.
PMID: 39442513
Spleen tyrosine kinase (SYK) is central to adaptive and innate immune signaling. It features a regulatory region containing tandem SH2 (tSH2) domains separated by a helical "hinge" segment keeping SYK...
3.
Du Y, Wang D, Katis V, Zoeller E, Qui M, Levey A, et al.
SLAS Discov
. 2024 Aug;
29(6):100177.
PMID: 39154664
The spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) interaction has a major role in the normal innate and adaptive immune responses, but dysregulation of...
4.
Du Y, Wang D, Katis V, Zoeller E, Qui M, Levey A, et al.
bioRxiv
. 2024 Jun;
PMID: 38915662
The spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) interaction has a major role in the normal innate and adaptive immune responses, but dysregulation of...
5.
Bielinski M, Henderson L, Yosaatmadja Y, Swift L, Baddock H, Bowen M, et al.
Chem Sci
. 2024 May;
15(21):8227-8241.
PMID: 38817593
The three human SNM1 metallo-β-lactamase fold nucleases (SNM1A-C) play key roles in DNA damage repair and in maintaining telomere integrity. Genetic studies indicate that they are attractive targets for cancer...
6.
de Souza Gama F, Dutra L, Hawgood M, Dos Reis C, Serafim R, Ferreira Jr M, et al.
J Med Chem
. 2024 May;
67(11):8609-8629.
PMID: 38780468
Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) are linked to various disease-relevant pathways. However, the lack of tool compounds for these kinases...
7.
Bashore F, Katis V, Du Y, Sikdar A, Wang D, Bradshaw W, et al.
PLoS One
. 2024 Feb;
19(2):e0293548.
PMID: 38359047
RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy....
8.
Bradshaw W, Kennedy E, Moreira T, Smith L, Chalk R, Katis V, et al.
Structure
. 2024 Feb;
32(4):453-466.e6.
PMID: 38309262
SHIP1, an inositol 5-phosphatase, plays a central role in cellular signaling. As such, it has been implicated in many conditions. Exploiting SHIP1 as a drug target will require structural knowledge...
9.
Du Y, Bradshaw W, Leisner T, Annor-Gyamfi J, Qian K, Bashore F, et al.
J Biol Chem
. 2023 Oct;
299(12):105382.
PMID: 37866628
Proteomic studies have identified moesin (MSN), a protein containing a four-point-one, ezrin, radixin, moesin (FERM) domain, and the receptor CD44 as hub proteins found within a coexpression module strongly linked...
10.
Bashore F, Katis V, Du Y, Sikdar A, Wang D, Bradshaw W, et al.
bioRxiv
. 2023 Aug;
PMID: 37547005
RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy....