George Posthuma
Overview
Explore the profile of George Posthuma including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
996
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Recent Articles
11.
Elgersma R, Kroon-Batenburg L, Posthuma G, Meeldijk J, Rijkers D, Liskamp R
Eur J Med Chem
. 2014 Aug;
88:55-65.
PMID: 25087966
Peptide and protein self-assembly resulting in the formation of amyloidogenic aggregates is generally thought of as a pathological event associated with severe diseases. However, amyloid formation may also provide a...
12.
de Jong O, Verhaar M, Chen Y, Vader P, Gremmels H, Posthuma G, et al.
J Extracell Vesicles
. 2013 Sep;
1.
PMID: 24009886
Background: The healthy vascular endothelium, which forms the barrier between blood and the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and inflammation by adaptation of...
13.
Wilson C, Parker L, Hall C, Smyczek T, Mak J, Crow A, et al.
Blood
. 2013 Jul;
122(22):3678-90.
PMID: 23886837
Establishment and stabilization of endothelial tubes with patent lumens is vital during vertebrate development. Ras-interacting protein 1 (RASIP1) has been described as an essential regulator of de novo lumenogenesis through...
14.
van Nispen tot Pannerden H, de Haas F, Geerts W, Posthuma G, van Dijk S, Heijnen H
Blood
. 2010 May;
116(7):1147-56.
PMID: 20439620
We have used (cryo) electron tomography to provide a 3-dimensional (3D) map of the intracellular membrane organization of human platelets at high spatial resolution. Our study shows that the open...
15.
Elgersma R, Posthuma G, Rijkers D, Liskamp R
J Pept Sci
. 2007 Sep;
13(11):709-16.
PMID: 17890652
This report reviews our approach to the design, synthesis and structural/morphological analysis of backbone-modified amylin(20-29) derivatives. Depending on the position in the peptide backbone and the type of amide bond...
16.
Hendrickx A, van Wamel W, Posthuma G, Bonten M, Willems R
J Bacteriol
. 2007 Sep;
189(22):8321-32.
PMID: 17873043
Most Enterococcus faecium isolates associated with hospital outbreaks and invasive infections belong to a distinct genetic subpopulation called clonal complex 17 (CC17). It has been postulated that the genetic evolution...
17.
van Donselaar E, Posthuma G, Zeuschner D, Humbel B, Slot J
Traffic
. 2007 Apr;
8(5):471-85.
PMID: 17451551
Immunogold labeling of cryosections according to Tokuyasu (Tokuyasu KT. A technique for ultracyotomy of cell suspensions and tissues. J Cell Biol 1973;57:551-565), is an important and widely used method for...
18.
Elgersma R, Mulder G, Kruijtzer J, Posthuma G, Rijkers D, Liskamp R
Bioorg Med Chem Lett
. 2007 Feb;
17(7):1837-42.
PMID: 17276062
The highly amyloidogenic peptide sequence of amylin(20-29) was transformed into its corresponding peptoid and retropeptoid sequences to design a novel class of beta-sheet breaker peptides as amyloid inhibitors. This report...
19.
van Wamel W, Hendrickx A, Bonten M, Top J, Posthuma G, Willems R
Infect Immun
. 2006 Nov;
75(2):924-31.
PMID: 17118984
A genetic subpopulation of Enterococcus faecium, called clonal complex 17 (CC-17), is strongly associated with hospital outbreaks and invasive infections. Most CC-17 strains contain a putative pathogenicity island encoding the...
20.
Elgersma R, Meijneke T, de Jong R, Brouwer A, Posthuma G, Rijkers D, et al.
Org Biomol Chem
. 2006 Sep;
4(19):3587-97.
PMID: 16990934
The incorporation of a single beta-aminoethane sulfonyl amide moiety in a highly amyloidogenic peptide sequence resulted in a complete loss of amyloid fibril formation. Instead, supramolecular folding morphologies were observed....