George N Henderson
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Explore the profile of George N Henderson including associated specialties, affiliations and a list of published articles.
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20
Citations
678
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Recent Articles
11.
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
Stacpoole P, Kerr D, Barnes C, Bunch S, Carney P, Fennell E, et al.
Pediatrics
. 2006 May;
117(5):1519-31.
PMID: 16651305
Objective: Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital lactic acidosis. We tested this hypothesis by conducting the first double-blind, randomized, control trial...
12.
Guo X, Dixit V, Liu H, Shroads A, Henderson G, James M, et al.
Drug Metab Dispos
. 2005 Oct;
34(1):36-42.
PMID: 16199472
Dichloroacetate (DCA) is an investigational drug for certain metabolic disorders, a by-product of water chlorination and a metabolite of certain industrial solvents and drugs. DCA is biotransformed to glyoxylate by...
13.
Quinlivan E, Davis S, Shelnutt K, Henderson G, Ghandour H, Shane B, et al.
J Nutr
. 2005 Mar;
135(3):389-96.
PMID: 15735068
The methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism is thought to influence the partitioning of 1-carbon units between methylation and other components of 1-carbon metabolism and to influence the risk and etiology...
14.
Felitsyn N, Henderson G, James M, Stacpoole P
Clin Chim Acta
. 2004 Nov;
350(1-2):219-30.
PMID: 15530481
Background: Several acquired and congenital human disorders perturb the concentrations of delta-aminolevulinate (delta-ALA), creatinine and tyrosine in biological fluids. There is currently no facile, sensitive and specific method to measure...
15.
Shelnutt K, Kauwell G, Gregory 3rd J, Maneval D, Quinlivan E, Theriaque D, et al.
J Nutr Biochem
. 2004 Sep;
15(9):554-60.
PMID: 15350988
DNA methylation is critical for normal genomic structure and function and is dependent on adequate folate status. A polymorphism (677C-->T) in a key folate enzyme, methylenetetrahydrofolate reductase (MTHFR), may impair...
16.
Shroads A, Henderson G, Cheung J, James M, Stacpoole P
J Chromatogr B Analyt Technol Biomed Life Sci
. 2004 Jul;
808(2):153-61.
PMID: 15261808
Tyrosine and many of its catabolites play significant roles in the in the toxicity associated with acquired and congenital forms of hypertyrosinemia. We now report a specific and sensitive GC/MS...
17.
Jia M, Wu W, Yost R, Chadik P, Stacpoole P, Henderson G
Anal Chem
. 2003 Nov;
75(16):4065-80.
PMID: 14632119
Haloacetic acids (HAAs) are environmentally and medically important chemicals. No analytical method is currently available to analyze EPA-regulated HAAs in biological samples at environmentally relevant low concentrations. Clinical studies of...
18.
Ammini C, Fernandez-Canon J, Shroads A, Cornett R, Cheung J, James M, et al.
Biochem Pharmacol
. 2003 Nov;
66(10):2029-38.
PMID: 14599561
Dichloroacetate (DCA) is both an environmental contaminant and an investigational drug for diseases involving perturbed mitochondrial energetics. DCA is biotransformed to glyoxylate by maleylacetoacetate isomerase (MAAI). Previous studies have shown...
19.
Agbenyega T, Planche T, Bedu-Addo G, Ansong D, Owusu-Ofori A, Bhattaram V, et al.
J Clin Pharmacol
. 2003 May;
43(4):386-96.
PMID: 12723459
The authors conducted a randomized, double-blind, placebo-controlled trial of intravenous dichloroacetate (DCA) for the purpose of treating lactic acidosis in 124 West African children with severe Plasmodium falciparum malaria. Lactic...
20.
Mackey A, Henderson G, Gregory 3rd J
J Biol Chem
. 2002 May;
277(30):26858-64.
PMID: 12023280
An obligatory step in the mammalian nutritional utilization of pyridoxine-5'-beta-D-glucoside (PNG) is the intestinal hydrolysis of its beta-glucosidic bond that releases pyridoxine (PN). This laboratory previously reported the purification and...