George H Rothblat
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Explore the profile of George H Rothblat including associated specialties, affiliations and a list of published articles.
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73
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5642
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Recent Articles
21.
Alexander E, Weibel G, Joshi M, Vedhachalam C, de la Llera-Moya M, Rothblat G, et al.
Arterioscler Thromb Vasc Biol
. 2009 Aug;
29(10):1496-501.
PMID: 19661486
Objective: To compare the abilities of human wild-type apoA-I (WT apoA-I) and human apoA-I(Milano) (apoA-I(M)) to promote macrophage reverse cholesterol transport (RCT) in apoA-I-null mice infected with adeno-associated virus (AAV)...
22.
Tanigawa H, Billheimer J, Tohyama J, Fuki I, Ng D, Rothblat G, et al.
Circulation
. 2009 Jul;
120(2):160-9.
PMID: 19564558
Background: Lecithin:cholesterol acyltransferase (LCAT) catalyzes the formation of plasma cholesteryl ester, plays a key role in high-density lipoprotein metabolism, and has been believed to be critical in the process of...
23.
Weibel G, Joshi M, Wei C, Bates S, Blair I, Rothblat G
J Lipid Res
. 2009 Jun;
50(12):2371-6.
PMID: 19528634
15(S)-lipoxygenase-1 (15-LO-1) was present in the whole-cell homogenate of an acute human monocytic leukemia cell line (THP-1). Additionally, 15-LO-1 was detected on neutral lipid droplets isolated from THP-1 foam cells....
24.
Weibel G, Joshi M, Alexander E, Zhu P, Blair I, Rothblat G
Arterioscler Thromb Vasc Biol
. 2009 Mar;
29(6):837-42.
PMID: 19325142
Objective: The purpose of this study was to determine the effect of 15-lipoxygenase-1 (15-LO-1) on cholesterol mobilization from macrophages. Methods And Results: Overexpression of human 15-LO-1 in RAW mouse macrophages...
25.
McGillicuddy F, de la Llera Moya M, Hinkle C, Joshi M, Chiquoine E, Billheimer J, et al.
Circulation
. 2009 Feb;
119(8):1135-45.
PMID: 19221221
Background: Inflammation is proposed to impair reverse cholesterol transport (RCT), a major atheroprotective function of high-density lipoprotein (HDL). The present study presents the first integrated functional evidence that inflammation retards...
26.
Rader D, Alexander E, Weibel G, Billheimer J, Rothblat G
J Lipid Res
. 2008 Dec;
50 Suppl:S189-94.
PMID: 19064999
Reverse cholesterol transport (RCT) is a term used to describe the efflux of excess cellular cholesterol from peripheral tissues and its return to the liver for excretion in the bile...
27.
Tohyama J, Billheimer J, Fuki I, Rothblat G, Rader D, Millar J
Atherosclerosis
. 2008 Nov;
204(2):418-23.
PMID: 18990393
Objective: The mechanism by which non-nucleoside reverse transcriptase inhibitors (NNRTIs) increase HDL cholesterol (HDL-C) in HIV+ patients and the benefits of this with respect to cardiovascular risk are not known....
28.
Sankaranarayanan S, Oram J, Asztalos B, Vaughan A, Lund-Katz S, Adorni M, et al.
J Lipid Res
. 2008 Oct;
50(2):275-84.
PMID: 18827283
Among the known mechanisms of reverse cholesterol transport (RCT), ATP binding cassette transporter G1 (ABCG1)-mediated free cholesterol (FC) transport is the most recent and least studied. Here, we have characterized...
29.
Duong P, Weibel G, Lund-Katz S, Rothblat G, Phillips M
J Lipid Res
. 2008 Feb;
49(5):1006-14.
PMID: 18252847
The contribution of ABCA1-mediated efflux of cellular phospholipid (PL) and cholesterol to human apolipoprotein A-I (apoA-I) to the formation of pre beta 1-HDL (or lipid-poor apoA-I) is not well defined....
30.
Bates S, Tao J, Yu K, Borok Z, Crandall E, Collins H, et al.
Am J Respir Cell Mol Biol
. 2007 Sep;
38(3):283-92.
PMID: 17884990
The mechanisms used by alveolar type I pneumocytes for maintenance of the lipid homeostasis necessary to sustain these large squamous cells are unknown. The processes may involve the ATP-binding cassette...