George Dubyak
Overview
Explore the profile of George Dubyak including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
243
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0
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Recent Articles
1.
Sahoo B, Mou Z, Liu W, Dubyak G, Dai X
Cell
. 2024 Dec;
188(2):292-302.e11.
PMID: 39667936
Ninjurin-1 (NINJ1) is an active executioner of plasma membrane rupture (PMR), a process previously thought to be a passive osmotic lysis event in lytic cell death. Ninjurin-2 (NINJ2) is a...
2.
Miller-Little W, Chen X, Salazar V, Liu C, Bulek K, Zhou J, et al.
Sci Immunol
. 2024 May;
9(95):eabq1558.
PMID: 38701190
Steroid resistance poses a major challenge for the management of autoimmune neuroinflammation. T helper 17 (T17) cells are widely implicated in the pathology of steroid resistance; however, the underlying mechanisms...
3.
Li Y, Wu S, Zhao Y, Dinh T, Jiang D, Selfridge J, et al.
J Clin Invest
. 2024 Jan;
134(5).
PMID: 38194275
Neutrophil extracellular traps (NETs), a web-like structure of cytosolic and granule proteins assembled on decondensed chromatin, kill pathogens and cause tissue damage in diseases. Whether NETs can kill cancer cells...
4.
Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, et al.
Nat Commun
. 2022 May;
13(1):2406.
PMID: 35504893
The C-type lectin receptor Mincle is known for its important role in innate immune cells in recognizing pathogen and damage associated molecular patterns. Here we report a T cell-intrinsic role...
5.
Panigrahi S, Bazdar D, Albakri M, Ferrari B, Antonelli C, Freeman M, et al.
Eur J Immunol
. 2020 Jun;
50(12):2055-2066.
PMID: 32548862
Recent studies have implicated a role for adenosine-dependent immunosuppression in head and neck tumor microenvironments. We describe expression of CD73, an enzyme critical to the generation of adenosine from extracellular...
6.
Zhang C, Jiang M, Zhou H, Liu W, Wang C, Kang Z, et al.
J Clin Invest
. 2018 Oct;
128(12):5399-5412.
PMID: 30372424
NLRP3 inflammasome plays a critical spatiotemporal role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). This study reports a mechanistic insight into noncanonical NLRP3 inflammasome activation in microglia for the...
7.
Martin B, Wang C, Willette-Brown J, Herjan T, Gulen M, Zhou H, et al.
Nat Commun
. 2014 Oct;
5:4977.
PMID: 25266676
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report that IκB kinase α (IKKα) is...
8.
Qiu J, Tsien C, Thapalaya S, Narayanan A, Weihl C, Ching J, et al.
Am J Physiol Endocrinol Metab
. 2012 Aug;
303(8):E983-93.
PMID: 22895779
Hyperammonemia and sarcopenia (loss of skeletal muscle) are consistent abnormalities in cirrhosis and portosystemic shunting. We have shown that muscle ubiquitin-proteasome components are not increased with hyperammonemia despite sarcopenia. This...