George Abruzzo
Overview
Explore the profile of George Abruzzo including associated specialties, affiliations and a list of published articles.
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8
Citations
146
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Recent Articles
1.
Wring S, Randolph R, Park S, Abruzzo G, Chen Q, Flattery A, et al.
Antimicrob Agents Chemother
. 2017 Feb;
61(4).
PMID: 28137806
SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β-(1,3)-d-glucan synthesis, an essential cell...
2.
Singh S, Liu W, Li X, Chen T, Shafiee A, Card D, et al.
ACS Med Chem Lett
. 2014 Jun;
3(10):814-7.
PMID: 24900384
Ilicicolin H is a polyketide-nonribosomal peptide synthase (NRPS)-natural product isolated from Gliocadium roseum, which exhibits potent and broad spectrum antifungal activity, with sub-μg/mL MICs against Candida spp., Aspergillus fumigatus, and...
3.
Singh S, Herath K, Nielsen Kahn J, Mann P, Abruzzo G, Motyl M
Bioorg Med Chem Lett
. 2013 Apr;
23(11):3253-6.
PMID: 23623416
Echinocandins and pneumocandins are classes of lipocyclohexapeptides that are broad spectrum antifungal agents. They inhibit fungal specific 1,3-β-glucan synthase activity which is an essential component of the fungal cell wall....
4.
Singh S, Ondeyka J, Harris G, Herath K, Zink D, Vicente F, et al.
J Nat Prod
. 2012 Dec;
76(3):334-45.
PMID: 23259972
Phaeofungin (1), a new cyclic depsipeptide isolated from Phaeosphaeria sp., was discovered by application of reverse genetics technology, using the Candida albicans fitness test (CaFT). Phaeofungin is comprised of seven...
5.
Ondeyka J, Harris G, Zink D, Basilio A, Vicente F, Bills G, et al.
J Nat Prod
. 2009 Jan;
72(1):136-41.
PMID: 19115836
A glycosylated tetramic acid, virgineone (1), was isolated from saprotrophic Lachnum virgineum. The antifungal activity of the fermentation extract of L. virgineum was characterized in the Candida albicans fitness test...
6.
Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, et al.
Bioorg Med Chem
. 2008 Dec;
17(3):1361-9.
PMID: 19112025
We isolated a cyclic lipodepsipeptide, phomafungin, from a Phoma sp. The distinct antifungal activity of phomafungin in the crude extract was initially discovered by mechanistic profiling in the Candida albicans...
7.
Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, et al.
Chem Biol
. 2008 Apr;
15(4):363-74.
PMID: 18420143
Natural products provide an unparalleled source of chemical scaffolds with diverse biological activities and have profoundly impacted antimicrobial drug discovery. To further explore the full potential of their chemical diversity,...
8.
Parish C, Huber J, Baxter J, Gonzalez A, Collado J, Platas G, et al.
J Nat Prod
. 2004 Dec;
67(11):1900-2.
PMID: 15568786
The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active...