Geoffrey G Hesketh
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Explore the profile of Geoffrey G Hesketh including associated specialties, affiliations and a list of published articles.
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33
Citations
1259
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Recent Articles
1.
Choi J, Luo J, Hesketh G, Guo S, Pistofidis A, Ladak R, et al.
Sci Adv
. 2024 Jul;
10(29):eadl5638.
PMID: 39018414
Viruses can selectively repress the translation of mRNAs involved in the antiviral response. RNA viruses exploit the Grb10-interacting GYF (glycine-tyrosine-phenylalanine) proteins 2 (GIGYF2) and eukaryotic translation initiation factor 4E (eIF4E)...
2.
Zhang C, Shafaq-Zadah M, Pawling J, Hesketh G, Dransart E, Pacholczyk K, et al.
J Biol Chem
. 2023 Nov;
299(12):105416.
PMID: 37918808
Proteostasis requires oxidative metabolism (ATP) and mitigation of the associated damage by glutathione, in an increasingly dysfunctional relationship with aging. SLC3A2 (4F2hc, CD98) plays a role as a disulfide-linked adaptor...
3.
Tan Y, Abbas Y, Wu J, Wu D, Keon K, Hesketh G, et al.
Life Sci Alliance
. 2022 Jul;
5(11).
PMID: 35794005
V-ATPases are rotary proton pumps that serve as signaling hubs with numerous protein binding partners. CryoEM with exhaustive focused classification allowed detection of endogenous proteins associated with porcine kidney V-ATPase....
4.
Coelho P, Hesketh G, Pedersen A, Kuzmin E, Fortier A, Bell E, et al.
Nat Commun
. 2022 Jul;
13(1):3812.
PMID: 35780247
Autophagy selectively targets cargo for degradation, yet mechanistic understanding remains incomplete. The ATG8-family plays key roles in autophagic cargo recruitment. Here by mapping the proximal interactome of ATG8-paralogs, LC3B and...
5.
Go C, Knight J, Rajasekharan A, Rathod B, Hesketh G, Abe K, et al.
Nature
. 2022 Jan;
602(7895):E16.
PMID: 35017685
No abstract available.
6.
Go C, Knight J, Rajasekharan A, Rathod B, Hesketh G, Abe K, et al.
Nature
. 2021 Jun;
595(7865):120-124.
PMID: 34079125
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct biochemical processes into discrete subcellular locations. Microscopy and biochemical fractionation coupled with mass spectrometry have defined the proteomes of...
7.
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex
Hirst J, Hesketh G, Gingras A, Robinson M
J Cell Biol
. 2021 Jan;
220(2).
PMID: 33464297
Adaptor protein complex 5 (AP-5) and its partners, SPG11 and SPG15, are recruited onto late endosomes and lysosomes. Here we show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells...
8.
Kim S, Choi J, Wang P, Go C, Hesketh G, Gingras A, et al.
Mol Cell
. 2020 Dec;
81(2):398-407.e4.
PMID: 33340489
Mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and proliferation by sensing fluctuations in environmental cues such as nutrients, growth factors, and energy levels. The Rag GTPases (Rags)...
9.
Hesketh G, Papazotos F, Pawling J, Rajendran D, Knight J, Martinez S, et al.
Science
. 2020 Oct;
370(6514):351-356.
PMID: 33060361
The mechanistic target of rapamycin complex 1 (mTORC1) couples nutrient sufficiency to cell growth. mTORC1 is activated by exogenously acquired amino acids sensed through the GATOR-Rag guanosine triphosphatase (GTPase) pathway,...
10.
Emmer B, Hesketh G, Kotnik E, Tang V, Lascuna P, Xiang J, et al.
Elife
. 2018 Sep;
7.
PMID: 30251625
PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory...