Geoffrey G Hesketh
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Explore the profile of Geoffrey G Hesketh including associated specialties, affiliations and a list of published articles.
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1259
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Recent Articles
11.
Hesketh G, Wartosch L, Davis L, Bright N, Luzio J
Prog Mol Subcell Biol
. 2018 Aug;
57:151-180.
PMID: 30097775
In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and...
12.
Khoriaty R, Hesketh G, Bernard A, Weyand A, Mellacheruvu D, Zhu G, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(33):E7748-E7757.
PMID: 30065114
Approximately one-third of the mammalian proteome is transported from the endoplasmic reticulum-to-Golgi via COPII-coated vesicles. SEC23, a core component of coat protein-complex II (COPII), is encoded by two paralogous genes...
13.
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B
Hunter M, Hesketh G, Benedyk T, Gingras A, Graham S
J Mol Biol
. 2018 May;
430(14):2153-2163.
PMID: 29778605
Multi-subunit tethering complexes control membrane fusion events in eukaryotic cells. Class C core vacuole/endosome tethering (CORVET) and homotypic fusion and vacuole protein sorting (HOPS) are two such complexes, both containing...
14.
Jafarnejad S, Chapat C, Matta-Camacho E, Gelbart I, Hesketh G, Arguello M, et al.
Elife
. 2018 Feb;
7.
PMID: 29412140
MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs. We recently discovered that the cap-binding protein 4EHP is...
15.
Hesketh G, Dennis J
Glycobiology
. 2017 Oct;
27(7):595-598.
PMID: 29048482
Pedersen et al. (Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, et al. 2016. Human gut microbes impact...
16.
Chapat C, Jafarnejad S, Matta-Camacho E, Hesketh G, Gelbart I, Attig J, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(21):5425-5430.
PMID: 28487484
MicroRNAs (miRNAs) play critical roles in a broad variety of biological processes by inhibiting translation initiation and by destabilizing target mRNAs. The CCR4-NOT complex effects miRNA-mediated silencing, at least in...
17.
Hesketh G, Youn J, Samavarchi-Tehrani P, Raught B, Gingras A
Methods Mol Biol
. 2017 Feb;
1550:115-136.
PMID: 28188527
Complete understanding of cellular function requires knowledge of the composition and dynamics of protein interaction networks, the importance of which spans all molecular cell biology fields. Mass spectrometry-based proteomics approaches...
18.
Waxse B, Sengupta P, Hesketh G, Lippincott-Schwartz J, Buss F
J Cell Sci
. 2017 Jan;
130(5):827-840.
PMID: 28096472
In this study, we demonstrate myosin VI enrichment at Cx43 (also known as GJA1)-containing gap junctions (GJs) in heart tissue, primary cardiomyocytes and cell culture models. In primary cardiac tissue...
19.
Dennis M, Delevoye C, Acosta-Ruiz A, Hurbain I, Romao M, Hesketh G, et al.
J Cell Biol
. 2016 Aug;
214(3):293-308.
PMID: 27482051
Endomembrane organelle maturation requires cargo delivery via fusion with membrane transport intermediates and recycling of fusion factors to their sites of origin. Melanosomes and other lysosome-related organelles obtain cargoes from...
20.
Hesketh G, Perez-Dorado I, Jackson L, Wartosch L, Schafer I, Gray S, et al.
Dev Cell
. 2014 May;
29(5):591-606.
PMID: 24856514
VARP is a Rab32/38 effector that also binds to the endosomal/lysosomal R-SNARE VAMP7. VARP binding regulates VAMP7 participation in SNARE complex formation and can therefore influence VAMP7-mediated membrane fusion events....