Seyed Mehdi Jafarnejad
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Explore the profile of Seyed Mehdi Jafarnejad including associated specialties, affiliations and a list of published articles.
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51
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1330
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Recent Articles
1.
Ladak R, Choi J, Luo J, Chen O, Mahmood N, He A, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(48):e2413018121.
PMID: 39560640
A critical host response against viral infections entails the activation of innate immune signaling that culminates in the production of antiviral proteins. DNA viruses are sensed by the cytosolic pattern...
2.
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, et al.
Nucleic Acids Res
. 2024 Oct;
52(20):12534-12548.
PMID: 39351862
Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its misincorporation into DNA and inhibition of thymidylate synthase....
3.
Choi J, Luo J, Hesketh G, Guo S, Pistofidis A, Ladak R, et al.
Sci Adv
. 2024 Jul;
10(29):eadl5638.
PMID: 39018414
Viruses can selectively repress the translation of mRNAs involved in the antiviral response. RNA viruses exploit the Grb10-interacting GYF (glycine-tyrosine-phenylalanine) proteins 2 (GIGYF2) and eukaryotic translation initiation factor 4E (eIF4E)...
4.
Lister K, Wong C, Uttam S, Parisien M, Stecum P, Brown N, et al.
bioRxiv
. 2024 Jul;
PMID: 38979173
Sensitization of spinal nociceptive circuits plays a crucial role in neuropathic pain. This sensitization depends on new gene expression that is primarily regulated via transcriptional and translational control mechanisms. The...
5.
McGirr T, Onar O, Jafarnejad S
FEBS J
. 2024 Jul;
292(5):936-959.
PMID: 38949989
Precise regulation of mRNA translation is of fundamental importance for maintaining homeostasis. Conversely, dysregulated general or transcript-specific translation, as well as abnormal translation events, have been linked to a multitude...
6.
Naeli P, Zhang X, Snell P, Chatterjee S, Kamran M, Ladak R, et al.
J Cell Sci
. 2023 Sep;
136(19).
PMID: 37732428
Viruses use microRNAs (miRNAs) to impair the host antiviral response and facilitate viral infection by expressing their own miRNAs or co-opting cellular miRNAs. miRNAs inhibit translation initiation of their target...
7.
Escos A, Diaz-Mora E, Pattison M, Fajardo P, Gonzalez-Romero D, Risco A, et al.
Elife
. 2023 Jul;
12.
PMID: 37458356
Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using -deficient (p38γ/δKO) mice, which show low levels of TPL2, the kinase upstream of MKK1-ERK1/2 in myeloid...
8.
Accogli A, Lin S, Severino M, Kim S, Huang K, Rocca C, et al.
Genet Med
. 2023 Jul;
25(11):100938.
PMID: 37454282
Purpose: Biallelic variants in TARS2, encoding the mitochondrial threonyl-tRNA-synthetase, have been reported in a small group of individuals displaying a neurodevelopmental phenotype but with limited neuroradiological data and insufficient evidence...
9.
Chalkiadaki K, Statoulla E, Zafeiri M, Haji N, Lacaille J, Powell C, et al.
Front Cell Dev Biol
. 2023 Jun;
11:1205112.
PMID: 37293130
Tuberous sclerosis complex (TSC) is a rare monogenic disorder co-diagnosed with high rates of autism and is caused by loss of function mutations in the TSC1 or TSC2 genes. A...
10.
Hoang H, Naeli P, Alain T, Jafarnejad S
Biochem Soc Trans
. 2023 May;
51(3):1047-1056.
PMID: 37199495
Interferons (IFNs) are crucial components of the cellular innate immune response to viral infections. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a remarkable capacity to suppress the...