Gatha Thacker
Overview
Explore the profile of Gatha Thacker including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
187
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Singh A, Thacker G, Upadhyay V, Mishra M, Sharma A, Sethi A, et al.
FEBS J
. 2024 Aug;
291(20):4539-4557.
PMID: 39110129
CCAAT/enhancer-binding protein α (C/EBPα), a key myeloid transcription factor, drives myeloid differentiation from blast cells by regulating the expression of granulocyte colony stimulating factor receptor and C/EBPε as required for...
2.
Mishra M, Singh A, Thacker G, Upadhyay V, Sanyal S, Trivedi A
Cell Biol Int
. 2023 Mar;
47(7):1247-1258.
PMID: 36950830
Ormeloxifene (ORM) (3,4-trans-2,2-dimethyl-3-phenyl-4-p-(β-pyrrolidinoethoxy) phenyl-7-methoxychroman), world's first nonsteroidal selective estrogen receptor modulator approved for contraception in India has been shown to have potential anticancer activities. Here, we show that ORM can...
3.
Thacker G, Henry S, Nandi A, Debnath R, Singh S, Nayak A, et al.
Sci Transl Med
. 2023 Mar;
15(686):eabl4414.
PMID: 36888695
Natural killer (NK) cells are cytotoxic lymphocytes that accumulate within the tumor microenvironment and are generally considered to be antitumorigenic. Using single-cell RNA sequencing and functional analysis of multiple triple-negative...
4.
Nandi A, Debnath R, Nayak A, To T, Thacker G, Reilly M, et al.
Cancer Res
. 2022 Aug;
82(20):3718-3733.
PMID: 36007109
Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.
5.
Sharma A, Thacker G, Mishra M, Singh A, Upadhyay V, Sanyal S, et al.
Life Sci
. 2022 Jun;
303:120682.
PMID: 35662647
Aim: Tamoxifen-mediated endocrine therapy has been standard treatment for ER+ breast cancers; however, majority of them acquire resistance leading to disease relapse. Although numerous substrates of E3 ligase FBW7 are...
6.
Singh S, Kumar S, Srivastava R, Nandi A, Thacker G, Murali H, et al.
Nat Cell Biol
. 2021 Aug;
23(9):1048.
PMID: 34349253
No abstract available.
7.
Thacker G, Mishra M, Sharma A, Singh A, Sanyal S, Trivedi A
Med Oncol
. 2021 May;
38(6):69.
PMID: 34002296
Transcription factor CCAAT/enhancer-binding protein-alpha (C/EBPα) regulates myelopoiesis by coupling growth arrest with differentiation of myeloid progenitors. Mutations in one or both alleles are observed in 10-14% AML cases that render...
8.
Sharma A, Upadhyay V, Sarkar M, Mishra M, Thacker G, Trivedi A
Biotechnol Appl Biochem
. 2021 Feb;
69(2):442-450.
PMID: 33559923
Imparting epithelial to mesenchymal transition (EMT) during cellular transformation, a major driving force behind tumor progression, is one of the notorious oncogenic activities of transforming growth factor β (TGFβ); however,...
9.
Mishra M, Thacker G, Sharma A, Singh A, Upadhyay V, Sanyal S, et al.
Mol Cancer Res
. 2020 Nov;
19(2):261-273.
PMID: 33188146
Glycogen synthase kinase 3β (GSK3β), an ubiquitously expressed serine/threonine kinase is reported to be overexpressed and hyperactivated in cancers including acute myeloid leukemia (AML) where it promotes self-renewal, growth, and...
10.
Sharma A, Mishra T, Thacker G, Mishra M, Narender T, Trivedi A
Cell Biol Int
. 2020 Sep;
44(12):2553-2569.
PMID: 32902904
Triple-negative breast cancers (TNBC) are highly aggressive and drug resistant accounting for majority of cases with poor outcome. Purified natural compounds display substantial anticancer activity with reduced cytotoxicity providing a...