Mukul Mishra
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Explore the profile of Mukul Mishra including associated specialties, affiliations and a list of published articles.
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11
Citations
40
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Recent Articles
1.
Singh A, Thacker G, Upadhyay V, Mishra M, Sharma A, Sethi A, et al.
FEBS J
. 2024 Aug;
291(20):4539-4557.
PMID: 39110129
CCAAT/enhancer-binding protein α (C/EBPα), a key myeloid transcription factor, drives myeloid differentiation from blast cells by regulating the expression of granulocyte colony stimulating factor receptor and C/EBPε as required for...
2.
Mishra M, Singh A, Thacker G, Upadhyay V, Sanyal S, Trivedi A
Cell Biol Int
. 2023 Mar;
47(7):1247-1258.
PMID: 36950830
Ormeloxifene (ORM) (3,4-trans-2,2-dimethyl-3-phenyl-4-p-(β-pyrrolidinoethoxy) phenyl-7-methoxychroman), world's first nonsteroidal selective estrogen receptor modulator approved for contraception in India has been shown to have potential anticancer activities. Here, we show that ORM can...
3.
Sharma A, Thacker G, Mishra M, Singh A, Upadhyay V, Sanyal S, et al.
Life Sci
. 2022 Jun;
303:120682.
PMID: 35662647
Aim: Tamoxifen-mediated endocrine therapy has been standard treatment for ER+ breast cancers; however, majority of them acquire resistance leading to disease relapse. Although numerous substrates of E3 ligase FBW7 are...
4.
Thacker G, Mishra M, Sharma A, Singh A, Sanyal S, Trivedi A
Med Oncol
. 2021 May;
38(6):69.
PMID: 34002296
Transcription factor CCAAT/enhancer-binding protein-alpha (C/EBPα) regulates myelopoiesis by coupling growth arrest with differentiation of myeloid progenitors. Mutations in one or both alleles are observed in 10-14% AML cases that render...
5.
Sharma A, Upadhyay V, Sarkar M, Mishra M, Thacker G, Trivedi A
Biotechnol Appl Biochem
. 2021 Feb;
69(2):442-450.
PMID: 33559923
Imparting epithelial to mesenchymal transition (EMT) during cellular transformation, a major driving force behind tumor progression, is one of the notorious oncogenic activities of transforming growth factor β (TGFβ); however,...
6.
Mishra M, Thacker G, Sharma A, Singh A, Upadhyay V, Sanyal S, et al.
Mol Cancer Res
. 2020 Nov;
19(2):261-273.
PMID: 33188146
Glycogen synthase kinase 3β (GSK3β), an ubiquitously expressed serine/threonine kinase is reported to be overexpressed and hyperactivated in cancers including acute myeloid leukemia (AML) where it promotes self-renewal, growth, and...
7.
Sharma A, Mishra T, Thacker G, Mishra M, Narender T, Trivedi A
Cell Biol Int
. 2020 Sep;
44(12):2553-2569.
PMID: 32902904
Triple-negative breast cancers (TNBC) are highly aggressive and drug resistant accounting for majority of cases with poor outcome. Purified natural compounds display substantial anticancer activity with reduced cytotoxicity providing a...
8.
Thacker G, Mishra M, Sharma A, Singh A, Sanyal S, Trivedi A
Life Sci
. 2020 Jul;
257:118041.
PMID: 32622945
Aim: Transcription factor CCAAT/Enhancer binding protein alpha (C/EBPα) is a key regulator of myeloid differentiation, granulopoiesis in particular. Although CEBPA mutations are found in more than 10% in AML, functional...
9.
Thacker G, Mishra M, Sharma A, Singh A, Sanyal S, Trivedi A
J Cell Biochem
. 2019 Nov;
121(4):2839-2850.
PMID: 31692040
Deregulation and functional inhibition of CCAAT-enhancer-binding protein α (C/EBPα), a key transcription factor of myeloid lineage leads to development of myeloid leukemia. In this study, we show that cyclin-dependent kinase...
10.
Mishra M, Sharma A, Thacker G, Trivedi A
IUBMB Life
. 2019 Jul;
71(12):1896-1905.
PMID: 31329371
E6AP (E6 associated protein) is a HECT domain containing protein having dual E3 ligase and ERα coactivation activity in breast cancer cells. Although E6AP is known to possess antitumorigenic activity,...