Gary P Brennan
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Explore the profile of Gary P Brennan including associated specialties, affiliations and a list of published articles.
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38
Citations
750
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Recent Articles
21.
Vangoor V, Reschke C, Senthilkumar K, van de Haar L, de Wit M, Giuliani G, et al.
J Neurosci
. 2019 Apr;
39(26):5064-5079.
PMID: 31015341
Mesial temporal lobe epilepsy (mTLE) is a chronic neurological disease characterized by recurrent seizures. The antiepileptic drugs currently available to treat mTLE are ineffective in one-third of patients and lack...
22.
Brennan G, Vitsios D, Casey S, Looney A, Hallberg B, Henshall D, et al.
PLoS One
. 2018 Dec;
13(12):e0207952.
PMID: 30507953
MicroRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. MicroRNAs have been identified in various body fluids under normal conditions and their stability...
23.
Raoof R, Bauer S, Naggar H, Connolly N, Brennan G, Brindley E, et al.
EBioMedicine
. 2018 Nov;
38:127-141.
PMID: 30396857
Background: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression,...
24.
Morris G, Brennan G, Reschke C, Henshall D, Schorge S
Epilepsia
. 2018 Jul;
59(8):1518-1526.
PMID: 29978460
Objective: Inhibition of microRNA-134 by an oligonucleotide antagomir (ant-134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the...
25.
Rajman M, Metge F, Fiore R, Khudayberdiev S, Aksoy-Aksel A, Bicker S, et al.
EMBO J
. 2017 May;
36(12):1770-1787.
PMID: 28487411
Synaptic downscaling is a homeostatic mechanism that allows neurons to reduce firing rates during chronically elevated network activity. Although synaptic downscaling is important in neural circuit development and epilepsy, the...
26.
Engel T, Martinez-Villarreal J, Henke C, Jimenez-Mateos E, Sanz-Rodriguez A, Alves M, et al.
Mol Neurodegener
. 2017 Feb;
12(1):21.
PMID: 28235423
Background: The ubiquitin-proteasome-system (UPS) is the major intracellular pathway leading to the degradation of unwanted and/or misfolded soluble proteins. This includes proteins regulating cellular survival, synaptic plasticity and neurotransmitter signaling;...
27.
Hall A, Brennan G, Nguyen T, Singh-Taylor A, Mun H, Sargious M, et al.
eNeuro
. 2017 Feb;
4(1).
PMID: 28197553
The mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults, including trauma, stroke, tumors, infections, and long seizures [status epilepticus (SE)], create a neuronal state of increased...
28.
Brennan G, Henshall D
Neurosci Lett
. 2017 Jan;
667:47-52.
PMID: 28104433
Temporal lobe epilepsy is a common and often drug-resistant seizure disorder. The underlying pathological processes which give rise to the development of spontaneous seizures include neuroinflammation, cell loss, neurogenesis and...
29.
Engel T, Brennan G, Sanz-Rodriguez A, Alves M, Beamer E, Watters O, et al.
Biochim Biophys Acta Mol Cell Res
. 2016 Nov;
1864(2):255-266.
PMID: 27840225
Cells have developed complex transcriptional regulatory mechanisms to maintain intracellular homeostasis and withstand pathophysiological stressors. Feed-forward loops comprising transcription factors that drive expression of both target gene and a microRNA...
30.
Quinlan S, Henke C, Brennan G, Henshall D, Jimenez-Mateos E
Methods Mol Biol
. 2016 Nov;
1509:85-91.
PMID: 27826920
MicroRNAs are key posttranscriptional regulators of protein levels in cells. The brain is particularly enriched in microRNAs, and important roles have been demonstrated for these noncoding RNAs in various neurological...