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David C Henshall

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Articles 202
Citations 5188
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Recent Articles
1.
Alves M, de Diego-Garcia L, Vegliante G, Moreno O, Gil B, Ramos-Cabrer P, et al.
Theranostics . 2025 Jan; 15(4):1399-1419. PMID: 39886340
Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent...
2.
Casillas-Espinosa P, Wong J, Grabon W, Gonzalez-Ramos A, Mantegazza M, Yilmaz N, et al.
Epilepsia . 2024 Nov; 66(2):328-340. PMID: 39560633
The early onset epilepsies encompass a heterogeneous group of disorders, some of which result in drug-resistant seizures, developmental delay, psychiatric comorbidities, and sudden death. Advancement in the widespread use of...
3.
Dwivedi A, Mahesh A, Sanfeliu A, Larkin J, Siwicki R, Sweeney K, et al.
JCI Insight . 2024 Nov; 10(1. PMID: 39541170
The availability and integration of electrophysiological and molecular data from the living brain is critical in understanding and diagnosing complex human disease. Intracranial stereo electroencephalography (SEEG) electrodes used for identifying...
4.
Yang M, You D, Liu G, Lu Y, Yang G, OBrien T, et al.
Sci Rep . 2024 Oct; 14(1):26106. PMID: 39478194
Induced pluripotent stem cell (iPSC) technology, in combination with electrophysiological characterization via multielectrode array (MEA), has facilitated the utilization of iPSC-derived motor neurons (iPSC-MNs) as highly valuable models for underpinning...
5.
Edoho M, Mamad O, Henshall D, Mooney C, Wei L
IEEE Trans Biomed Eng . 2024 Oct; 72(3):978-987. PMID: 39412970
Objective: Animal models of drug-resistant epilepsy represent an important resource for discovering new drug targets and testing experimental medicines. Intra-amygdala microinjection of kainic acid in mice is one of the...
6.
Cases-Cunillera S, Quatraccioni A, Rossini L, Ruffolo G, Ono T, Baulac S, et al.
Epilepsia . 2024 Oct; 65(12):3457-3468. PMID: 39401070
Epilepsy represents a common neurological disorder in patients with developmental brain lesions, particularly in association with malformations of cortical development and low-grade glioneuronal tumors. In these diseases, genetic and molecular...
7.
Quatraccioni A, Cases-Cunillera S, Balagura G, Coleman M, Rossini L, Mills J, et al.
Epilepsia . 2024 Sep; 65(11):3138-3154. PMID: 39302576
Early onset epilepsies occur in newborns and infants, and to date, genetic aberrations and variants have been identified in approximately one quarter of all patients. With technological sequencing advances and...
8.
Harnett A, Mathoux J, Wilson M, Heiland M, Mamad O, Srinivas S, et al.
Eur J Neurosci . 2024 Aug; 60(6):5266-5283. PMID: 39149798
Epilepsy is a neurological disease characterised by recurrent seizures with complex aetiology. Temporal lobe epilepsy, the most common form in adults, can be acquired following brain insults including trauma, stroke,...
9.
De Meulemeester A, Reid C, Auvin S, Carlen P, Cole A, Szlendak R, et al.
Epilepsia . 2024 Jul; 65(9):2553-2566. PMID: 39042520
Epilepsy has a peak incidence during the neonatal to early childhood period. These early onset epilepsies may be severe conditions frequently associated with comorbidities such as developmental deficits and intellectual...
10.
Khemka N, Morris G, Kazemzadeh L, Costard L, Neubert V, Bauer S, et al.
Sci Rep . 2024 Jul; 14(1):15313. PMID: 38961125
Epileptogenesis is the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous recurrent seizures. The extensive dysregulation of gene expression associated with epileptogenesis is shaped, in...