Gary P Brennan
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Explore the profile of Gary P Brennan including associated specialties, affiliations and a list of published articles.
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38
Citations
750
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Recent Articles
11.
Brennan G, Garcia-Curran M, Patterson K, Luo R, Baram T
Front Neurol
. 2021 Mar;
12:615802.
PMID: 33679583
Bi-directional neuronal-glial communication is a critical mediator of normal brain function and is disrupted in the epileptic brain. The potential role of aberrant microglia and astrocyte function during epileptogenesis is...
12.
Reschke C, Silva L, Vangoor V, Rosso M, David B, Cavanagh B, et al.
Mol Ther
. 2021 Feb;
29(6):2041-2052.
PMID: 33609732
Oligonucleotide therapies offer precision treatments for a variety of neurological diseases, including epilepsy, but their deployment is hampered by the blood-brain barrier (BBB). Previous studies showed that intracerebroventricular injection of...
13.
Wilson M, Henshall D, Byrne S, Brennan G
Int J Mol Sci
. 2021 Jan;
22(2).
PMID: 33435571
Epileptic encephalopathies (EE) are severe epilepsy syndromes characterized by multiple seizure types, developmental delay and even regression. This class of disorders are increasingly being identified as resulting from de novo...
14.
Conboy K, Henshall D, Brennan G
Neurobiol Dis
. 2020 Nov;
148:105179.
PMID: 33181318
Epilepsy is a network disorder driven by fundamental changes in the function of the cells which compose these networks. Driving this aberrant cellular function are large scale changes in gene...
15.
Almeida Silva L, Reschke C, Nguyen N, Langa E, Sanz-Rodriguez A, Gerbatin R, et al.
Mol Brain
. 2020 Aug;
13(1):114.
PMID: 32825833
MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. Sequencing as well as functional studies using antisense oligonucleotides indicate important roles for microRNAs during the development of epilepsy...
16.
Brennan G, Bauer S, Engel T, Jimenez-Mateos E, Del Gallo F, Hill T, et al.
Neurobiol Dis
. 2020 Aug;
144:105048.
PMID: 32800995
Epilepsy diagnosis is complex, requires a team of specialists and relies on in-depth patient and family history, MRI-imaging and EEG monitoring. There is therefore an unmet clinical need for a...
17.
Casey S, Goasdoue K, Miller S, Brennan G, Cowin G, OMahony A, et al.
Mol Neurobiol
. 2020 Jul;
57(10):4322-4344.
PMID: 32720074
Hypoxic ischemic encephalopathy (HIE) is the most frequent cause of acquired infant brain injury. Early, clinically relevant biomarkers are required to allow timely application of therapeutic interventions. We previously reported...
18.
Veno M, Reschke C, Morris G, Connolly N, Su J, Yan Y, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(27):15977-15988.
PMID: 32581127
Temporal lobe epilepsy is the most common drug-resistant form of epilepsy in adults. The reorganization of neural networks and the gene expression landscape underlying pathophysiologic network behavior in brain structures...
19.
Brennan G, Henshall D
Nat Rev Neurol
. 2020 Jun;
16(9):506-519.
PMID: 32546757
Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the primary clinical symptom of the epilepsies. Brain tissue from animal models and patients with acquired forms of epilepsy...
20.
Batool A, Hill T, Nguyen N, Langa E, Diviney M, Mooney C, et al.
Front Neurosci
. 2020 Feb;
13:1404.
PMID: 32009885
Repetitive or prolonged seizures (status epilepticus) can damage neurons within the hippocampus, trigger gliosis, and generate an enduring state of hyperexcitability. Recent studies have suggested that microvesicles including exosomes are...