Gareth J Browne
Overview
Explore the profile of Gareth J Browne including associated specialties, affiliations and a list of published articles.
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17
Citations
1270
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0
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Recent Articles
1.
Matas-Cespedes A, Lapointe J, Elder M, Browne G, Dovedi S, de Haan L, et al.
Front Immunol
. 2023 Mar;
14:1107848.
PMID: 36936963
Introduction: Humanized mice are emerging as valuable models to experimentally evaluate the impact of different immunotherapeutics on the human immune system. These immunodeficient mice are engrafted with human cells or...
2.
Orozco C, Bersellini M, Irving L, Howard W, Hargreaves D, Devine P, et al.
MAbs
. 2022 Jul;
14(1):2095701.
PMID: 35799328
Although monoclonal antibodies have greatly improved cancer therapy, they can trigger side effects due to on-target, off-tumor toxicity. Over the past decade, strategies have emerged to successfully mask the antigen-binding...
3.
Dovedi S, Elder M, Yang C, Sitnikova S, Irving L, Hansen A, et al.
Cancer Discov
. 2021 Jan;
11(5):1100-1117.
PMID: 33419761
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that...
4.
Hay J, Jordan E, Browne G, Bottrill A, Prigent S, Dickens M
J Mol Signal
. 2018 Sep;
12:3.
PMID: 30210579
Myocyte Stress Protein 1 (MS1) is a muscle-specific, stress-responsive, regulator of gene expression. It was originally identified in embryonic mouse heart which showed increased expression in a rat model of...
5.
Caramel J, Papadogeorgakis E, Hill L, Browne G, Richard G, Wierinckx A, et al.
Cancer Cell
. 2013 Oct;
24(4):466-80.
PMID: 24075834
Aberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and metastatic dissemination. We found that regulation and functions of EMT-TFs are different...
6.
Morel A, Hinkal G, Thomas C, Fauvet F, Courtois-Cox S, Wierinckx A, et al.
PLoS Genet
. 2012 Jun;
8(5):e1002723.
PMID: 22654675
The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT-inducing transcription factors are aberrantly expressed in multiple tumor types...
7.
Browne G, Dickens M
J Recept Signal Transduct Res
. 2011 Nov;
31(6):408-15.
PMID: 22070384
ASK1 is a cellular stress-responsive MAPKKK which activates the JNK and p38 MAPK pathways that play a key role in the response of cardiac myocytes to redox stress following ischemia/reperfusion....
8.
Sayan B, Yang A, Conforti F, Tucci P, Piro M, Browne G, et al.
Proc Natl Acad Sci U S A
. 2010 Jul;
107(29):12877-82.
PMID: 20615966
p73 is a p53-related transcription factor with fundamental roles in development and tumor suppression. Transcription from two different promoters on the p73 gene results in generation of transcriptionally active TAp73...
9.
Harding S, Browne G, Miller B, Prigent S, Dickens M
Biochim Biophys Acta
. 2010 Jun;
1802(9):733-40.
PMID: 20550965
p38 MAPK is activated potently during cardiac ischaemia, although the precise mechanism by which it is activated is unclear. We used the isolated perfused rat heart to investigate the signalling...
10.
Sayan A, Griffiths T, Pal R, Browne G, Ruddick A, Yagci T, et al.
Proc Natl Acad Sci U S A
. 2009 Aug;
106(35):14884-9.
PMID: 19706487
The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB family members, ZEB1 and ZEB2(SIP1), inhibit transcription of the E-cadherin gene and induce EMT in vitro. However, their relevance to...