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Galit Shahaf

Explore the profile of Galit Shahaf including associated specialties, affiliations and a list of published articles. Areas
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Articles 20
Citations 453
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Recent Articles
11.
Bellacen K, Kalay N, Ozeri E, Shahaf G, Lewis E
Cell Transplant . 2012 Oct; 22(11):2119-33. PMID: 23050776
Pancreatic islets are a highly vascularized entity, and their transplantation into diabetic individuals requires optimal revascularization. In addition, β-cells in islets are extremely sensitive to inflammation. α-1-Antitrypsin (AAT), a circulating...
12.
Twina G, Sheiner E, Shahaf G, Yaniv Salem S, Madar T, Baron J, et al.
J Matern Fetal Neonatal Med . 2012 Jul; 25(12):2667-70. PMID: 22746289
Objective: α-1 antitrypsin (AAT) is an anti-protease, anti-inflammatory and tissue-protective molecule. Normal circulating levels are <3.5 mg/dl and rise during pregnancy. Although AAT deficiency is associated with several pregnancy and...
13.
Ozeri E, Mizrahi M, Shahaf G, Lewis E
J Immunol . 2012 May; 189(1):146-53. PMID: 22634621
Tolerogenic IL-10-positive CCR7-positive dendritic cells (DC) promote T regulatory (Treg) cell differentiation upon CCR7-dependent migration to draining lymph nodes (DLN). Indeed, in human DC deficiencies, Treg levels are low. α-1...
14.
Shahaf G, Rotem-Dai N, Koifman G, Raveh-Amit H, Frost S, Livneh E
Exp Cell Res . 2012 Feb; 318(7):789-99. PMID: 22305966
The PI3K-AKT pathway is frequently activated in human cancers, including breast cancer, and its activation appears to be critical for tumor maintenance. Some malignant cells are dependent on activated AKT...
15.
Baron J, Sheiner E, Abecassis A, Ashkenazi E, Shahaf G, Yaniv Salem S, et al.
J Matern Fetal Neonatal Med . 2011 Aug; 25(7):934-7. PMID: 21843112
Objective: α1-antitrypsin (AAT) is protective of tissue damage induced by enzymes of inflammatory cell source. Inflammatory cells are involved in preterm labor, preterm premature rupture of membrane (PPROM) and term...
16.
Raveh-Amit H, Hai N, Rotem-Dai N, Shahaf G, Gopas J, Livneh E
Biochem Biophys Res Commun . 2011 Aug; 412(2):313-7. PMID: 21820409
The nuclear factor κB (NF-κB) family of transcription factors participates in the regulation of genes involved in innate- and adaptive-immune responses, cell death and inflammation. The involvement of the Protein...
17.
Shahaf G, Moser H, Ozeri E, Mizrahi M, Abecassis A, Lewis E
Mol Med . 2011 Jun; 17(9-10):1000-11. PMID: 21670848
Antiinflammatory clinical-grade, plasma-derived human α-1 antitrypsin (hAAT) protects islets from allorejection as well as from autoimmune destruction. hAAT also interferes with disease progression in experimental autoimmune encephalomyelitis (EAE) and in...
18.
Subramanian S, Shahaf G, Ozeri E, Miller L, Vandenbark A, Lewis E, et al.
Metab Brain Dis . 2011 Mar; 26(2):107-13. PMID: 21437674
Alpha-1-antitrypsin (AAT) is the primary circulating serine protease inhibitor, and is known to exert potent anti-inflammatory effects and to inhibit the progression of several autoimmune diseases. In this study, transgenic...
19.
Gurevitch D, Boura-Halfon S, Isaac R, Shahaf G, Alberstein M, Ronen D, et al.
Diabetes . 2010 Jun; 59(9):2188-97. PMID: 20547979
Objective: Cellular stress and proinflammatory cytokines induce phosphorylation of insulin receptor substrate (IRS) proteins at Ser sites that inhibit insulin and IGF-1 signaling. Here, we examined the role of Ser...
20.
Maissel A, Marom M, Shtutman M, Shahaf G, Livneh E
Cell Signal . 2005 Oct; 18(8):1127-39. PMID: 16242915
Protein kinase C (PKC) represents a family of serin/threonine kinases, playing a central role in the regulation of cell growth, differentiation and transformation. These enzymes differ in their primary structure,...