Eli C Lewis
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Explore the profile of Eli C Lewis including associated specialties, affiliations and a list of published articles.
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79
Citations
2241
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Recent Articles
1.
El-Saied S, Kaminer B, Kaplan D, Shitrit R, Manilis I, Amar A, et al.
Otol Neurotol
. 2024 Jun;
45(7):818-823.
PMID: 38896787
Aim: To characterize vestibular recovery in a mouse model of unilateral labyrinthotomy under local AAT and dexamethasone treatment. Background: Alpha1-antitrypsin (AAT) is a circulating tissue-protective molecule that rises during inflammatory...
2.
El-Saied S, Amar A, Kaplan D, Shitrit R, Kaminer B, Keshet A, et al.
Laryngoscope
. 2024 Apr;
134(8):3802-3806.
PMID: 38651563
Background: Most tympanic membrane (TM) perforations heal spontaneously, but 10%-20% remain chronic and might lead to impaired hearing and recurrent middle ear infections. Alpha1-antitrypsin (AAT) is a circulating tissue-protective protein...
3.
Brami I, Zuckerman T, Ram R, Avni B, Peretz G, Ostrovsky D, et al.
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203593
α1-Antitrypsin (AAT), an acute-phase reactant not unsimilar to C-reactive protein (CRP), is a serine protease inhibitor that harbors tissue-protective and immunomodulatory attributes. Its concentrations appropriately increase during conditions of extensive...
4.
Gimmon A, Sherker L, Kojukarov L, Zaknoun M, Lior Y, Fadel T, et al.
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806370
Wound healing requires a non-compromising combination of inflammatory and anti-inflammatory processes. Human α1-antitrypsin (hAAT), a circulating glycoprotein that rises during acute-phase responses and during healthy pregnancies, is tissue-protective and tolerance-inducing;...
5.
Segal L, Lewis E
Cell Immunol
. 2022 Apr;
375:104528.
PMID: 35468329
α1-antitrypsin (AAT) is an acute-phase protein that functions as an inhibitor of serine proteases, such as neutrophil elastase. A significant body of evidence shows that AAT has a pivotal role...
6.
Lior Y, Shtriker E, Kahremany S, Lewis E, Gruzman A
Eur J Med Chem
. 2021 Nov;
228:113969.
PMID: 34763945
Human α1-antitrypsin (hAAT) has two distinguishing functions: anti-protease activity and regulation of the immune system. In the present study we hypothesized that those two protein functions are mediated by different...
7.
Beckerman M, Harel C, Michael I, Klip A, Bilan P, Gallagher E, et al.
Sci Adv
. 2021 Oct;
7(42):eabg3947.
PMID: 34644106
Skeletal muscle insulin resistance is a main defect in type 2 diabetes (T2D), which is associated with impaired function and content of glucose transporter type 4 (GLUT4). GLUT4 overexpression in...
8.
Ozeri E, Rider P, Rigbi S, Shahaf G, Nita I, Sekler I, et al.
Cell Immunol
. 2021 Jan;
361:104281.
PMID: 33453508
Dendritic cells (DCs) mature upon an inflammatory trigger. However, an inflammatory trigger can lead to a semi-mature phenotype, allowing DCs to evoke tolerance and expedite the resolution of inflammation. This...
9.
Sutter M, Cremona T, Nita I, Cavarra E, Lungarella G, Lewis E, et al.
Pharmaceutics
. 2020 Aug;
12(9).
PMID: 32825773
Rationale: Mutation in the alpha1 antitrypsin (AAT) gene leads to low circulating levels of AAT, which is associated with several disease processes including pulmonary emphysema. The standard of care relies...
10.
El-Saied S, Zaknoun M, Alatawna O, Joshua B, Kabahaa N, Kaplan D, et al.
Cell Immunol
. 2020 Aug;
356:104150.
PMID: 32823037
Transient vestibular organ deafferentation, such that is caused by traumatic tissue injury, is presently addressed by corticosteroid therapy. However, restoration of neurophysiological properties is rarely achieved. Here, it was hypothesized...