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Boris M Baranovski

Explore the profile of Boris M Baranovski including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 115
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Recent Articles
1.
Schuster R, Motola-Kalay N, Baranovski B, Bar L, Tov N, Stein M, et al.
Cell Immunol . 2020 Aug; 356:104177. PMID: 32795666
Alpha1-antitrypsin (AAT) is a serum protease inhibitor that rises during inflammation and healthy pregnancies. Plasma-derived AAT, indicated for genetic AAT deficiency, is presently being explored for additional medical indications. Unlike...
2.
Cerqueira F, Kozer N, Petcherski A, Baranovski B, Wolf D, Assali E, et al.
Biochem J . 2020 Feb; 477(2):461-475. PMID: 32003437
Mitochondrial turnover is required for proper cellular function. Both mitochondrial biogenesis and mitophagy are impaired in several degenerative and age-related diseases. The search for mitophagy activators recently emerged as a...
3.
Baranovski B, Schuster R, Nisim O, Brami I, Lior Y, Lewis E
Chronic Obstr Pulm Dis . 2019 Feb; 5(4):267-276. PMID: 30723784
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder which most commonly manifests as pulmonary emphysema. Accordingly, alpha-1 antitrypsin (AAT) augmentation therapy aims to reduce the progression of emphysema, as achieved...
4.
Lior Y, Zaretsky M, Ochayon D, Lotysh D, Baranovski B, Schuster R, et al.
Front Immunol . 2018 May; 9:759. PMID: 29780379
Introduction: Human α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase a sequence-specific molecular protrusion (reactive center loop, RCL; positions 357-366). hAAT formulations that lack...
5.
Baranovski B, Ozeri E, Shahaf G, Ochayon D, Schuster R, Bahar N, et al.
J Pharmacol Exp Ther . 2016 Nov; 359(3):482-490. PMID: 27821710
Life-long weekly infusions of human α1-antitrypsin (hAAT) are currently administered as augmentation therapy for patients with genetic AAT deficiency (AATD). Several recent clinical trials attempt to extend hAAT therapy to...
6.
Ochayon D, Baranovski B, Malkin P, Schuster R, Kalay N, Ben-Hamo R, et al.
Cell Transplant . 2016 Feb; 25(8):1575-88. PMID: 26850009
Immune tolerance toward "self" is critical in multiple immune disorders. While there are several mechanisms to describe the involvement of immune cells in the process, the role of peripheral tissue...
7.
Cerqueira F, Chausse B, Baranovski B, Liesa M, Lewis E, Shirihai O, et al.
FEBS J . 2016 Jan; 283(5):822-33. PMID: 26732506
β-cells quickly adjust insulin secretion to oscillations in nutrients carried by the blood, acting as fuel sensors. However, most studies of β-cell responses to nutrients do not discriminate between fuel...
8.
Baranovski B, Freixo-Lima G, Lewis E, Rider P
Biomed Res Int . 2015 Nov; 2015:184574. PMID: 26583093
The traditional model of T helper differentiation describes the naïve T cell as choosing one of several subsets upon stimulation and an added reciprocal inhibition aimed at maintaining the chosen...
9.
Kaner Z, Ochayon D, Shahaf G, Baranovski B, Bahar N, Mizrahi M, et al.
J Infect Dis . 2014 Nov; 211(9):1489-98. PMID: 25389308
Background: Severe bacterial infection can cause sepsis, multiple organ dysfunction syndrome (MODS), and death. Human α1-antitrypsin (hAAT) is an antiinflammatory, immune-modulating, and tissue-protective circulating serine-protease inhibitor, with levels that increase...
10.
Ochayon D, Mizrahi M, Shahaf G, Baranovski B, Lewis E
Front Immunol . 2013 Nov; 4:320. PMID: 24191154
The extracellular form of the abundant heat-shock protein, gp96, is involved in human autoimmune pathologies. In patients with type 1 diabetes, circulating gp96 is found to be elevated, and is...