Gabrielle Fredman
Overview
Explore the profile of Gabrielle Fredman including associated specialties, affiliations and a list of published articles.
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65
Citations
4012
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Recent Articles
1.
Groenen A, Lipscomb M, Ramos R, Sadhu S, Bazioti V, Fredman G, et al.
Prostaglandins Leukot Essent Fatty Acids
. 2024 Aug;
202:102634.
PMID: 39167848
Aging is associated with systemic, non-resolving inflammation and the accumulation of senescent cells. The resolution of inflammation (or inflammation-resolution) is in part mediated by the balance between specialized pro-resolving mediators...
2.
Chen Z, Aikawa E, Alfaidi M, Ali K, Clift C, Erbay E, et al.
Arterioscler Thromb Vasc Biol
. 2024 Jul;
44(9):1916-1924.
PMID: 38957985
Institutional support is crucial for the successful career advancement of all faculty but in particular those who are women. Evolving from the past, in which gender disparities were prevalent in...
3.
Grazda R, Seyfried A, Maddipati K, Fredman G, MacNamara K
Cell Death Dis
. 2024 May;
15(5):324.
PMID: 38724533
Severe aplastic anemia (SAA) is a rare, fatal disease characterized by severe cytopenias and loss of hematopoietic stem cells (HSCs). Immune-mediated destruction and inflammation are known drivers of SAA, however,...
4.
Lipscomb M, Walis S, Marinello M, Mena H, MacNamara K, Spite M, et al.
FASEB J
. 2024 Mar;
38(6):e23555.
PMID: 38498346
Dysregulated inflammation-resolution programs are associated with atherosclerosis progression. Resolvins, in part, mediate inflammation-resolution programs. Indeed, Resolvin D2 (RvD2) activates GPR18, a G-protein-coupled receptor, and limits plaque progression, though the cellular...
5.
Fredman G, Serhan C
Nat Rev Cardiol
. 2024 Jan;
21(11):808-823.
PMID: 38216693
Timely resolution of the acute inflammatory response (or inflammation resolution) is an active, highly coordinated process that is essential to optimal health. Inflammation resolution is regulated by specific endogenous signalling...
6.
Izquierdo M, Harris M, Shanmugarajah N, Zhong K, Ozcan L, Fredman G, et al.
bioRxiv
. 2023 Oct;
PMID: 37905094
Background–: Type 2 diabetes is associated with an increased risk of atherosclerotic cardiovascular disease. It has been suggested that insulin resistance underlies this link, possibly by altering the functions of...
7.
Fredman G, Khan S
Immunol Rev
. 2023 Oct;
319(1):151-157.
PMID: 37787174
The failure to resolve inflammation underpins to several prevalent diseases, like atherosclerosis, and so identifying ways to boost resolution is unmet clinical needs. The resolution of inflammation is governed by...
8.
Fitzgerald H, Bonin J, Khan S, Eid M, Sadhu S, Rahtes A, et al.
Am J Pathol
. 2023 Sep;
193(12):1953-1968.
PMID: 37717941
Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts through the G-protein-coupled receptor called GPR18. Unbiased RNA sequencing revealed increased Gpr18...
9.
Spite M, Fredman G
Adv Pharmacol
. 2023 May;
97:257-281.
PMID: 37236761
Non-resolving inflammation is an underpinning of cardiovascular diseases including atherosclerosis. The resolution of inflammation is an active and highly coordinated process that involves the generation of specialized pro-resolving mediators (SPMs),...
10.
Abi-Ghanem C, Salinero A, Kordit D, Mansour F, Kelly R, Venkataganesh H, et al.
Biol Sex Differ
. 2023 May;
14(1):31.
PMID: 37208759
Background: Damage to the cerebral vasculature can lead to vascular contributions to cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to neuropathology, including neuroinflammation...